Postoperative analgesia in patients with stenotic lesions of the carotid arteries

   This paper presents a comparative study of the use of the analgesic Tafalgin in the first 24 hours after carotid endarterectomy.

   The aim of the research. Analysis and comparison of the safety of analgesia with Tafalgin and trimeperidine in patients after carotid endarterectomy.

   Materials and methods. The study included 80 patients who underwent eversion carotid endarterectomy. Patients were divided into two groups: Group I (Trimeperidine) and Group II (Tafalgin). The incidence of side effects in the early postoperative period was analyzed. Pain intensity was assessed using the Visual Analog Scale (VAS). Patient satisfaction with pain relief and physician satisfaction with the quality of pain relief (Likert scale) were analyzed.

   Results. Thirty minutes after anesthesia, a reduction in pain sensations was achieved from the initial values (Group I – 60 ± 5 mm, Group II – 55 ± 5 mm) to 40 ± 5 mm and 35 ± 5 mm, respectively. The difference in the analgesic effect between the groups was not significant. After 2 hours, the VAS score was 25 ± 5 mm in the Tafalgin group and 30 ± 5 mm in the Trimeperidine group. After 6, 12, and 24 hours, patients reported virtually no pain. In the Trimeperidine group, the incidence of side effects was higher. An analysis of physician satisfaction with the pain relief provided in the Tafalgin group showed better results compared to the Trimeperidine group. In the Tafalgin group, all patients were satisfied with the quality of analgesia, while in the Trimeperidine group, 5 patients gave an unsatisfactory rating.

   Conclusion. The new peptide analgesic Tafalgin has demonstrated its efficacy and safety in postoperative pain relief in patients with stenotic lesions of the carotid arteries.

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