THE IMPACT OF NON-MOTOR SYMPTOMS OF PARKINSON'S DISEASE ON THE PATIENTS` QUALITY OF LIFE
https://doi.org/10.52485/19986173_2022_1_56
Abstract
Parkinson's disease is a chronic neurodegenerative disease that manifests with motor symptoms such as hypokinesia, muscle rigidity and resting tremors, as well as a wide range of non-motor disorders. It has now been established that non-motor symptoms of the disease contribute significantly to a decrease in the quality of life of patients. The aim of this review is to study the effect of non-motor symptoms on the quality of life of patients with Parkinson's disease and to determine the most valid scales for assessing the quality of life. We searched for scientific articles - the results of clinical studies in the RSCI and PubMed databases using the keywords “Parkinson's disease”, “non-motor symptoms” and “Quality of life”. The study showed that non-motor symptoms have a significant negative impact on the quality of life of patients with Parkinson's disease, in particular depression. To assess the quality of life, the universal scale SF-36 and the specific scale PDQ-39 are mainly used. At the same time, there is insufficient data on the impact of ethnicity and socio-economic status of patients with Parkinson's disease on the quality of life, there is no information on the role of non-drug methods, for example, schools of patients with Parkinson's disease.
About the Authors
L. I. Кopylova
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
27 Oyunsky str., 677013, Yakutsk
T. Ya. Nicolaeva
M.K. Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
27 Oyunsky str., 677013, Yakutsk
A. A. Tappakhov
M.K. Ammosov North-Eastern Federal University; Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
27 Oyunsky str., 677013, Yakutsk
6/3 Yaroslavsky str., Yakutsk, 677000
T. E. Popova
Yakutsk Scientific Center for Complex Medical Problems
Russian Federation
Russian Federation
6/3 Yaroslavsky str., Yakutsk, 677000
References
1. Illarioshkin S.N., Levin O.S.,editors. Guidelines for the diagnosis and treatment of Parkinson's disease. Moscow. Medpress-pm. 2019. in Russian.
2. Titova N.V., Chaudhuri K.R. Non-motor symptoms of Parkinson’s disease: the submerged part of the iceberg. Annals of Clinical and Experimental Neurology. 2017. 11 (4). 5-18. doi: 10.18454/ACEN.2017.4.1
3. Cerri S., Mus L., Blandini F. Parkinson's Disease in Women and Men: What's the Difference? J Parkinsons Dis. 2019. 9 (3). 501-515. doi: 10.3233/JPD-191683.
4. Nodel N.P., Yahno N.N. editors. Non-motor disorders in parkinsons disease and their impact on quality of life: guide for doctors. In: Rukovodstvo dlja vrachej po materialam 1 nacional'nogo kongressa. Moscow. RKI Sovero press. 2008. 92-93. in Russian.
5. Levin O.S., Artem'ev D.V., Bril' E.V., Kulua T.K. Parkinson's disease: modern approaches to diagnosis and treatment. Practical medicine. 2017. 1 (102). 45-51. in Russian.
6. Gusev E.I., Konovalov A.N., Skvorsova V.I., Geht A.B. National guidelines. Moscow. Geotar-media. 2018.
7. Tappakhov A.A., Popova T.E., Nicolaeva T.Ya., Schnaider N.A., Petrova M.M., Sapronova M.R. Neuropsychological pattern of Parkinsons disease. Nevrologija, nejropsihiatrija, psihosomatika. 2017. 9 (4). 82-87. In Russian doi: 10.14412/2074-2711-2017-4-82-87.
8. Reichmann H. Premotor Diagnosis of Parkinson's Disease. Neurosci Bull. 2017. 33 (5). 526-534. doi: 10.1007/s12264-017-0159-5.
9. Torgan T.I. Fatigue syndrome and other non-motor symptoms of Parkinson`s disease and their impact on quality of life. Permskij medicinskij zhurnal. 2012. 6 (29). 11-17. In Russian.
10. Zhao N., Yang Y., Zhang L., Zhang Q., Balbuena L., Ungvari G., Zang Y., Xiang Y. Quality of life in Parkinson's disease: A systematic review and meta-analysis of comparative studies. CNS Neurosci Ther. 2021. 27 (3). 270-279. doi: 10.1111/cns.13549.
11. Nodel M. R. The impact of neuropsychiatric symptoms on quality of life of patients with Parkinson’s disease. Nevrologicheskiy zhurnal. 2015. 20 (1). 20–27.
12. Khegaj O.V., Selyanina N.V., Karakulova Ju.V. Influence of nonmotor manifestations of parkinsons disease on quality of life. Permskij medicinskij zhurnal. 2018. 5. 6-11. In Russian. doi: 10.17816/pmj3556-11.
13. Goncharova Z.A., Gelpey M.A., Rabadanova E.A. The influence of non-motor symptoms on the course of Parkinsons disease and the quality of life of patients. Saratovskij nauchno-medicinskij zhurnal. 2016. 12 (3). 362–366. in Russian.
14. Hermanowicz N., Jones S.A., Hauser R.A. Impact of non-motor symptoms in Parkinson's disease: a PMDAlliance survey. Neuropsychiatr Dis Treat. 2019. 5 (15). 2205-2212. doi: 10.2147/NDT.S213917.
15. Opara J.A., Brola W., Leonardi M., Błaszczyk B. Quality of life in Parkinson's disease. J Med Life. 2012. 5 (4). 375-381.
16. Schrag A., Jahanshahi M., Quinn N. What contributes to quality of life in patients with Parkinson's disease? J Neurol Neurosurg Psychiatry. 2000. 69 (3). 308-312. doi: 10.1136/jnnp.69.3.308.
17. Liu W.M., Lin R.J., Yu R.L., Tai C.H., Lin C.H., Wu R.M. The impact of nonmotor symptoms on quality of life in patients with Parkinson's disease in Taiwan. Neuropsychiatr Dis Treat. 2015. 11. 2865-2873. doi: 10.2147/NDT.S88968.
18. Gan J., Zhou M., Chen W., Liu Z. Non-motor symptoms in Chinese Parkinson’s disease patients. Journal of Clinical Neuroscience. 2014. 21 (5). 751–754. doi: 10.1016/j.jocn.2013.07.015.
19. Rabadanova E.A., Gelpey M.A., Goncharova Z.A. Non-motor symptoms of Parkinsons disease, their structure and impact on the quality of life of patients. Prakticheskaja medicina. 2015. 5 (90). 111-115. in Russian.
20. Bycov Yu. N., Bender T.B., Vasiliev Yu. N., Kaljagin A.N., Maksikova T.M., Orlova G.M., Kozlova N.M., Ryzhkova O.V. Impact of stimulating cognitive-motor training on neuropsychological status and quality of life in patients with Parkinsons disease. Nevrologija, nejropsihiatrija, psihosomatika. 2018. 10 (4). 65–71. In Russian. Doi: 10.14412/2074-2711-2018-4-65-71.
Review
For citations:
Кopylova L.I., Nicolaeva T.Ya., Tappakhov A.A., Popova T.E. THE IMPACT OF NON-MOTOR SYMPTOMS OF PARKINSON'S DISEASE ON THE PATIENTS` QUALITY OF LIFE. Transbaikalian Medical Bulletin. 2022;(1):56-61. (In Russ.) https://doi.org/10.52485/19986173_2022_1_56
Views:
91
Email this article 