Aims. To assess microcirculation in patients with severe pneumonia with A(H1N1) influenza.

Materials and methods. The study included 30 patients with severe pneumonia with A(H1N1) influenza. The CURB/CRB-65 scales were used to diagnose and assess the severity of pneumonia; SMART-COP, as well as the Federal Clinical Guidelines of the Ministry of Health of the Russian Federation "Community-Acquired Pneumonia in Adults" and the IDSA/ATS criteria. The SOFA scale was used to assess the degree of organ dysfunction. Patients were divided into 2 groups: group 1 (n=20), without signs of organ dysfunction (≤ 2 points on the SOFA scale), group 2 (n=10), with signs of organ dysfunction (≥ 2 points on the SOFA scale). The control group consisted of 15 healthy volunteers. The parameters of microcirculation were assessed by the method of laser Doppler flowmetry (LDF), on the device LAKK-02 (NPP Lazma, Russia).

Results. It was found that in patients with severe pneumonia with signs of organ dysfunction, the microcirculation index decreased, neurogenic and myogenic tone increased, the bypass index increased, both relative to the control group and relative to patients with severe pneumonia without signs of organ dysfunction.

Conclusion. A decrease in the microcirculation index and an increase in the bypass index, on the one hand, reflect the degree of microcirculatory disorders, while, on the other hand, these changes, being pathophysiological components of microhemodynamic insufficiency, contribute to the development of organ dysfunction in patients with severe pneumonia with A(H1N1) influenza.

The aim of the research. To study the incidence of rotavirus infection in children of the first year of life were hospitalized in regional clinical infectious diseases hospital with acute intestinal infection in the period from 2014 to 2020.

Materials and methods of research. The analysis of the data of statistical reports of the regional clinical infectious diseases hospital of Chita for 2014-2020 was carried out. Statistical processing was carried out using programs STATISTICA 10.0, Microsoft Office Exсel 2010.

Results. The number of hospitalizations of infants for acute intestinal infection decreased by 1,8 times in 2020 (p ˂ 0,05) compared to 2014, the incidence decreased by 43,1 %. The morbidity rate of viral diarrhea in the structure of acute intestinal infections of infancy averaged 31,7 %. In dynamics, an increase in the incidence of diarrhea of viral etiology was noted with an average growth rate of 10,3 %. The morbidity rate of rotavirus infection in infants was 73,9 %. In 2019, a decrease in the incidence of infants with rotavirus diarrhea by 1,4 times (p ˂ 0,05) was registered with an increase in diseases caused by viruses of other etiology.

Conclusions. The reduction in the number of hospitalizations in 2020 of infants with acute intestinal infection during the period of restrictive measures for COVID-19 revealed. There was a decrease in the incidence of acute intestinal infections in children of the first year of life in the period from 2014 to 2019. There was an increase in the morbidity rate of diarrhea of viral etiology and at the same time a decrease in the proportion of rotavirus infection.

The aim of the research. The fat tissue studying is area of different fields of medicine. The adipose tissue topography and its content in the human body are responsible for development socially significant diseases. Search new data of the fat tissue in according sex and body types needs additional studies.

Materials and methods. Participants were 228 males and 270 females aged 17–20 years. Thickness of fat folds was performed on eight areas of the body by J. Matiegka's method. The body types were determined by the index of sexual dimorphism of J. Tanner. All analyses were performed by SPSS v. 22.0. The data were analyzed by methods of non-parametric statistics: the Mann–Whitney U test, the chi-squared test and Spearman's rank correlation coefficient.

Results. The skin fold measurements showed that males and females of the andromorphic body type had the largest skin folds, then the same measures of mesomorphic and gynecomorphic body types of both sexes. The absolute value of the adipose tissue was examined in andromorphic males and females. The studying of the subcutaneous adipose tissue topography didn’t' have any differences between the study males and females different types of the sexual dimorphism.

Conclusion. The mesomorphic body type is the most common body type of the participants. The body type is characterized features of physique dysplasia to the opposite sex. Males and females of andromorphic body type have higher of skin-fold thickness and content of fat, then young people who are mesomorphic and gynecomorphic.

Objective. To determine predictors of aspirin resistance among atherothrombotic ischemic stroke patients considering demographic and clinical characteristics.

Materials and Methods. We examined 100 patients with atherothrombotic stroke hospitalized to the

Regional Vascular Center (Yakutsk) in 2020-2021. Platelet aggregation measured by a computerized whole blood Multiplate aggregometer on the 5th-7th day after the acetylsalicylic acid therapy initiation. To search for predictors of the development of aspirin resistance, the examined group's clinical and demographic characteristics investigated.

Results. No relationship was found between the development of aspirin resistance and race (p=0.052). There was an association between the presence of diabetes mellitus and high aggregometry scores (p=0.042; OR=0.412; 95 % CI: 0.173-0.979). Smoking, alcohol abuse and previous stroke were not significant for the development of aspirin resistance (p = 0.585; p = 0.158; p = 0.656, respectively). High lipid spectrum values were also associated with the risk of developing aspirin resistance (p = 0.01 for CH, p = 0.034 for LDL, p = 0.021 for HDL). NIHSS stroke severity was not associated with the platelet aggregation scores (p=0.297 at admission and p=0.108 at discharge). Hepatopathies were statistically significantly related with the increasing platelet aggregation (p = 0.001; OR=0.123; 95 % CI: 0.032-0.471). A dose-dependent effect of antiaggregant therapy was found. Aspirin dose was inversely associated with platelet aggregation scores (p < 0.001; OR=0.318; 95 % CI: 0.234-0.432).

Conclusion. The findings prove the connection between the degree of platelet aggregation and diabetes mellitus. The liver diseases of various etiologies are aspirin resistance predictors. The dose of the prescribed antiplatelet directly affects the level of platelet aggregation. The phenomenon of aspirin resistance needs further research with the use of molecular genetic testing techniques.

The aim of the research. Evaluate the impact of the new connection VMA-10-18 on performance mice in the test «Running on a treadmill» with subsequent evaluation of some biochemical parameters of animals.

Materials and methods. Physical activity was reproduced on the model of the test «Running on a treadmill» with subsequent blood sampling and assessment of biochemical parameters. The test compound and reference drug were administered per os at the respective doses of 10 mg/kg and 25 mg/kg 1 hour before exercise for 10 days. Preliminary assessment of lactate ion and glucose was carried out before the animals started running (day 1) and after the end of the ten-day experiment.

Results and discussions. During the study, it was found that the use of the test compound at a dose of 10 mg/kg increased the endurance of the animals in the experiment, as evidenced by the increase in the duration of the running of mice. The peak physical activity of the group receiving the studied compound was 2.6 times higher (p < 0.05) relative to the day of maximum endurance of the negative control group. It should be noted that lactate, as well as the level of glucose after exercise in this group, was lower by 3.3 (p < 0.05) and 1.8 times (p < 0.05), compared with the negative group. control.

Conclusion. VMA-10-18 improves the performance and endurance of animals against the background of debilitating loads, while correcting the resulting metabolic disorders.

Cerebrovascular diseases (CVD) are the main cause of disability and mortality in the adult population in the Russian Federation, the USA and European countries. The most severe form of CVD is acute cerebrovascular accident (ACVA). Despite significant progress in organizing medical care for patients who have suffered from an acute vascular accident, the mortality rate from this pathology in the Russian Federation remains one of the highest ones in the world. Ischemic stroke is a multifactorial disease based on risk factors, their correction significantly reduces the frequency of cerebral ischemia. The literature review presents modern epidemiological data on cerebrovascular pathology, highlights the pathogenetic classification of ischemic stroke, and considers the main risk factors for its occurrence.

The article provides a brief review of the literature on the main methods and tools of the concept of lean manufacturing, implemented in the healthcare system. The practical aspects of using the principles of lean manufacturing in healthcare are analyzed.

Taking into account the existing knowledge about heart damage in the case of a new coronavirus infection in children, there are many gaps and vulnerabilities that can cause new problems or exacerbate old ones. Since the disease is relatively young, it takes a lot of time to fully study its characteristics.

Complications from the cardiovascular system in children give an opportunity to think about the impact on the further development of the child's body. The world medical community at this stage of the development of the disease gathers the acquired experience together and contributes to the development of new methods of treatment and rehabilitation.

In a literature review, we reviewed a number of studies published over the past 10 years in order to identify the features of the development of coronary atherosclerosis in patients with type 2 diabetes mellitus in combination with coronary heart disease. This article includes possible blood markers as predictors of coronary artery disease. The review summarizes materials on the pathogenetic mechanisms of the influence of diabetes mellitus on the features of the development of atherosclerosis of the coronary arteries. Data from articles on patients with type 2 diabetes were summarized and presented descriptively.

This review provides information on the history of discovery, structure, and principles of functioning of the voltage-gated potassium ion channel Kv7.1 (KCNQ1). Current data on the physiological role of Kv7.1 in various organs and tissues are presented. The main pathological conditions associated with mutations in the gene encoding Kv7.1 are described.

Idiopathic autoimmune encephalitis with antibodies to NMDA receptors (EA to NMDAR) is a severe disease of the nervous system characterized by a variety of neuropsychiatric pathology and an involvement of neurotransmitter systems. Due to the wide distribution of the glutamatergic system in the central nervous system, the disease has a severe course, prominent psychotic symptoms with polymorphic neurological pathology. The predominance of acute psychosis at the onset, a diverse clinical picture with a low diagnostic value of neuroimaging (MRI) causes difficulties in establishing a diagnosis and prescribing early pathogenetic therapy.

The article describes a clinical case of EA to NMDAr in a child that arose subacutely and manifested itself as severe mental disorders with further neurological disorders. Given the severity of mental disorders in a patient in childhood age, the rarity of this pathology, the statement of the diagnosis was accompanied by certain difficulties.

The article summarizes the literature data on a rare pathology – Wilson disease in children. The review cites the case of the personal clinical observation of the complicated diagnosis and successful treatment of a girl with this disease. In the patient the disease debuted as hepatitis with the detection of Ebstein-Barr viruses and herpes type 6. The persisting syndrome of cytolysis after antiviral therapy necessitated the differential diagnosis of non-infectious liver pathology. Identified violations of copper metabolism, low levels of ceruloplasmin, molecular genetic study made it possible to clarify the diagnosis and prescribe pathogenetic treatment. The presented case complements the data available in the literature on Wilson's disease.