Microflora and bacterial traps in the pathogenesis of periodontitis
https://doi.org/10.52485/19986173_2026_1_120
Abstract
The primary etiological factor for the onset and progression of periodontitis is biofilm, an organized accumulation of microorganisms within a complex intercellular matrix. Multispecies biofilms demonstrate sophisticated communication between bacteria and maintain symbiotic relationships via quorum sensing (QS) within the microbiome [1].
Bacterial extracellular vesicles (BEVs) are considered key mediators of communication among bacteria themselves and with host cells [2, 3].
Bacterial vesicles provide a selective advantage to parent cells, promote biofilm formation and expansion, participate in the transport of virulence factors and genetic information, transform immune cells, can disseminate over long distances, and play a crucial role in disease development. This review analyzes the role of BEVs in the communication between bacteria and host cells and examines key pathways of inflammation and immune resistance.
Keywords
Supporting agencies: The study had no financial support
About the Authors
E. T. Domanova
Chita State Medical Academy, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Candidate of Medical Sciences, Assistant
Faculty of Advanced Training and Professional Retraining; Department of Dentistry
672000; 39a Gorky St.; Chita
AuthorID 670785
N. N. Tsybikov
Chita State Medical Academy, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Head of the Department
Department of Pathophysiology
672000; 39a Gorky St.; Chita
Researcher IDААА-8365-2020, AuthorID RSCI 520407, AuthorID Scopus 57202693187
V. V. Zobnin
Chita State Medical Academy, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head of the Department
Faculty of Advanced Training and Professional Retraining; Department of Dentistry
672000; 39a Gorky St.; Chita
Author ID RSCI 692134
M. V. Smirnitskaya
Chita State Medical Academy, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor
Faculty of Advanced Training and Professional Retraining; Department of Dentistry
672000; 39a Gorky St.; Chita
AuthorID RSCI 580392
I. I. Dedyukhin
Chita State Medical Academy, Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dentist, Resident
Faculty of Advanced Training and Professional Retraining; Department of Dentistry
672000; 39a Gorky St.; Chita
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Review
For citations:
Domanova E.T., Tsybikov N.N., Zobnin V.V., Smirnitskaya M.V., Dedyukhin I.I. Microflora and bacterial traps in the pathogenesis of periodontitis. Transbaikalian Medical Bulletin. 2026;(1):120-129. (In Russ.) https://doi.org/10.52485/19986173_2026_1_120
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