References

zabmedvestnik

Забайкальский медицинский вестник

Transbaikalian Medical Bulletin

1998-6173

Читинская государственная медицинская академия

10.52485/19986173_2026_1_120

zabmedvestnik-498

Research Article

НАУЧНЫЕ ОБЗОРЫ

SCIENTIFIC REVIEWS

Микрофлора и бактериальные ловушки в патогенезе пародонтита

Microflora and bacterial traps in the pathogenesis of periodontitis

https://orcid.org/0000-0002-3156-4840

Доманова

Е. Т.

Domanova

E. T.

Елена Товьевна Доманова, к. м. н., ассистент

ФДПО; кафедра стоматологии

672000; ул. Горького, 39а; Чита

AuthorID 670785

Candidate of Medical Sciences, Assistant

Faculty of Advanced Training and Professional Retraining; Department of Dentistry

672000; 39a Gorky St.; Chita

AuthorID 670785

l.domanova@yandex.ru

https://orcid.org/0000-0002-0975-2351

Цыбиков

Н. Н.

Tsybikov

N. N.

Намжил Нанзатович Цыбиков, д. м. н., профессор, заведующий кафедрой

кафедра патофизиологии

672000; ул. Горького, 39а; Чита

Researcher IDААА-8365-2020, AuthorID РИНЦ 520407, AuthorID Scopus 57202693187

Doctor of Medical Sciences, Professor, Head of the Department

Department of Pathophysiology

672000; 39a Gorky St.; Chita

Researcher IDААА-8365-2020, AuthorID RSCI 520407, AuthorID Scopus 57202693187

thybikov@mail.ru

https://orcid.org/0009-0003-4116-1951

Зобнин

В. В.

Zobnin

V. V.

Валерий Валерьевич Зобнин, к.м.н., заведующий кафедрой

ФДПО; кафедра стоматологии

672000; ул. Горького, 39а; Чита

Author ID РИНЦ 692134

Candidate of Medical Sciences, Head of the Department

Faculty of Advanced Training and Professional Retraining; Department of Dentistry

672000; 39a Gorky St.; Chita

Author ID RSCI 692134

v.zobninstom@yandex.ru

https://orcid.org/0009-0002-7737-2040

Смирницкая

М. В.

Smirnitskaya

M. V.

Марина Валентиновна Смирницкая, к. м. н., доцент

ФДПО; кафедра стоматологии

672000; ул. Горького, 39а; Чита

AuthorID РИНЦ 580392

Candidate of Medical Sciences, Associate Professor

Faculty of Advanced Training and Professional Retraining; Department of Dentistry

672000; 39a Gorky St.; Chita

AuthorID RSCI 580392

mary-sm@list.ru

https://orcid.org/0009-0004-2714-874X

Дедюхин

И. И.

Dedyukhin

I. I.

Илья Игоревич Дедюхин, врач-стоматолог, ординатор

ФДПО; кафедра стоматологии

672000; ул. Горького, 39а; Чита

Dentist, Resident

Faculty of Advanced Training and Professional Retraining; Department of Dentistry

672000; 39a Gorky St.; Chita

ii.dedyukhin@mail.ru

ФГБОУ ВО «Читинская государственная медицинская академия» Министерства здравоохранения РФРоссияChita State Medical Academy, Ministry of Health of the Russian FederationRussian Federation

2026

19052026

01120129

2026

Доманова Е.Т., Цыбиков Н.Н., Зобнин В.В., Смирницкая М.В., Дедюхин И.И.

Domanova E.T., Tsybikov N.N., Zobnin V.V., Smirnitskaya M.V., Dedyukhin I.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.zabmedvestnik.ru/jour/article/view/498

Основным этиологическим фактором возникновения и прогрессирования пародонтита является биоплёнка – организованное скопление микроорганизмов в сложном межклеточном матриксе. Мультивидовые биоплёнки демонстрируют сложные коммуникации между бактериями и поддерживают симбиотические связи – чувства кворума (QS-quorum sensing) в микробиоме [1].

Ключевыми посредниками коммуникации бактерий между собой или клетками организма-хозяина, считаются бактериальные внеклеточные везикулы (ВEV – Bacterial Extracellular Vesicles) [2, 3].

Бактериальные везикулы обеспечивают селективное преимущество родительским клеткам, способствуют образованию биоплёнок, расширению границ, участвуют в транспорте вирулентных факторов, переносе генетической информации между клетками, могут распространяться на большие расстояния и играть ключевую роль в развитии болезней. В этом обзоре была проанализирована роль BEV в коммуникации между бактериями и клетками организма-хозяина, рассмотрены ключевые механизмы воспаления и иммунной резистентности.

The primary etiological factor for the onset and progression of periodontitis is biofilm, an organized accumulation of microorganisms within a complex intercellular matrix. Multispecies biofilms demonstrate sophisticated communication between bacteria and maintain symbiotic relationships via quorum sensing (QS) within the microbiome [1].

Bacterial extracellular vesicles (BEVs) are considered key mediators of communication among bacteria themselves and with host cells [2, 3].

Bacterial vesicles provide a selective advantage to parent cells, promote biofilm formation and expansion, participate in the transport of virulence factors and genetic information, transform immune cells, can disseminate over long distances, and play a crucial role in disease development. This review analyzes the role of BEVs in the communication between bacteria and host cells and examines key pathways of inflammation and immune resistance.

зубная биопленкачувство кворумавоспалениепародонтитбактериальные внеклеточные везикул

dental biofilmquorum sensinginflammationperiodontitisbacterial extracellular vesicles

Исследование не имело финансовой поддержки

The study had no financial support

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The authors declare that there are no conflicts of interest present.