ATYPICAL HEMOLYTIC-UREMIC SYNDROME ASSOCIATED WITH ANTIBODIES TO FACTOR H IN PEDIATRIC PRACTICE
https://doi.org/10.52485/19986173_2025_4_136
Abstract
Atypical hemolytic-uremic syndrome (aHUS) is a serious problem in pediatrics and pediatric nephrology due to its severe course, tendency to progression, high mortality, and unresolved issues of early diagnosis and therapy. This circumstance dictates the need to improve existing diagnostic approaches and allows timely detection of aHUS and initiation of treatment at an early stage, which will significantly increase the chances of a favorable outcome. This publication presents 2 clinical cases of aHUS associated with antibodies to factor H in patient K., 4 years old, and patient U., 5 years old, who were treated at the state budgetary healthcare institution Children's Regional Clinical Hospital of the Ministry of Health of the Krasnodar Territory. Both children were admitted to the aHUS clinic, but genetic studies have not revealed mutations in specific genes associated with this disease. An increased titer of antibodies to factor H was found, which may indicate an acquired form of thrombotic microangiopathy. Positive dynamics was observed against the background of complement inhibitory therapy
About the Authors
A. V. Burluckaya
Kuban State Medical University
Russian Federation
Russian Federation
Burluckaya A.V., Doctor of Medical Sciences, Professor, Head of the Department of Pediatrics
Mitrofana 4 Sedina st., Krasnodar, 350063
A. V. Statova
Kuban State Medical University
Russian Federation
Russian Federation
Statova A.V., Associate Professor of the Department of Pediatrics
Mitrofana 4 Sedina st., Krasnodar, 350063
O. Yu. Zenkina
Kuban State Medical University
Russian Federation
Russian Federation
Zenkina O.Yu., Assistant of the Department of Pediatrics
Mitrofana 4 Sedina st., Krasnodar, 350063
D. A. Inozemceva
Kuban State Medical University
Russian Federation
Russian Federation
Inozemceva D.A., resident of the Department of Pediatrics
Mitrofana 4 Sedina st., Krasnodar, 350063
V. V. Golub
Children’s Regional Clinical Hospital, Ministry of Health
Russian Federation
Russian Federation
Golub V.V., Head of the Nephrology Department of the State Budgetary Healthcare Institution
1 Pobedy st., Krasnodar, Krasnodar Krai, 350007
Y. D. Kryukova
Children’s Regional Clinical Hospital, Ministry of Health
Russian Federation
Russian Federation
Kryukova Y.D., Nephrology Department physician
1 Pobedy st., Krasnodar, Krasnodar Krai, 350007
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Review
For citations:
Burluckaya A.V., Statova A.V., Zenkina O.Yu., Inozemceva D.A., Golub V.V., Kryukova Y.D. ATYPICAL HEMOLYTIC-UREMIC SYNDROME ASSOCIATED WITH ANTIBODIES TO FACTOR H IN PEDIATRIC PRACTICE. Transbaikalian Medical Bulletin. 2025;(4):136-146. (In Russ.) https://doi.org/10.52485/19986173_2025_4_136
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