ASCHERMAN SYNDROME: FROM ETIOLOGY TO PREVENTION
https://doi.org/10.52485/19986173_2024_2_122
Abstract
Asherman's syndrome is a mysterious, multifaceted disease characterized by the formation of
intrauterine synechiae, up to complete obliteration of the uterine cavity. This is a very controversial topic
because of its pronounced effect on both the reproductive prognosis (infertility, habitual miscarriage) and
gynecological symptoms (menstrual dysfunction of the type of oligo-amenorrhea). Although the syndrome
has been extensively studied, there is no clear evidence of both its prevention and effective treatment. The
main reason for the formation of intrauterine adhesions is recognized by most authors as endometrial injury.
Understanding the pathogenesis of their formation is necessary to prevent the development of endometrial
fibrosis and sclerosis. The review article presents in detail the causes of the disease, risk factors, clinical
manifestations, and methods for diagnosing this syndrome. Therapeutic measures are presented in step-bystep low-traumatic ways to eliminate intrauterine adhesions with subsequent restoration of menstrual and
reproductive functions. Particular attention is paid to anti-relapse prevention through the prescription of
intrauterine anti-adhesion gels.
About the Authors
O. V. RemnevaRussian Federation
40 Lenina av., Barnaul, 656038
O. A. Belnickaya
Russian Federation
40 Lenina av., Barnaul, 656038
M. B. Igitova
Russian Federation
40 Lenina av., Barnaul, 656038
N. I. Fadeeva
Russian Federation
40 Lenina av., Barnaul, 656038
S. F. Garanin
Russian Federation
40 Lenina av., Barnaul, 656038
References
1. Lee W.L., Liu C.H., Cheng M., et al. Focus on the Primary Prevention of Intrauterine Adhesions: Current Concept and Vision. Int. J. Mol. Sci. 2021. 13. 22 (10). 5175.
2. Orazov M.R., Mikhaleva L.M., Ismailzade S.Ya. Risk factors for the implementation of intrauterine adhesions in women of reproductive age. Medicinskij vestnik Yuga Rossii. 2022. 13 (2). 86-90. in Russian.
3. Orazov M.R., Mikhaleva L.M., Ismailzade S.Ya., Soyunov M.A. Intrauterine synechiae: an old problem, a new look. Klinicheskij razbor v obshhej medicine. 2023. 4 (9). 36-40. doi:10.47407/kr2023.4.9.00306. in Russian.
4. Arutyunova E.E., Buralkina N.A., Chuprynin V.D., et al. Pathogenetic justification and experience of using anti-adhesive gel in patients with intrauterine synechiae after surgical hysteroscopy. Meditsinskiy sovet. 2018.13. 160–64. in Russian.
5. Hooker A.B., de Leeuw R.A., Twisk J.W.R. Brölmann H.A.M., Huirne J.A.F. Reproductive performance of women with and without intrauterine adhesions following recurrent dilatation and curettage for miscarriage: long-term follow-up of a randomized controlled trial. Hum Reprod. 2021. 36 (1). 70–81.
6. Bespalova A. G., Popov A.A., Fedorov A.A., Tyurina S.S., Koval A.A. Intrauterine adhesion at reproductive age: an intergrated approach to solving the problem. Rossiyskiy vestnik akushera-ginekologa. 2021.21 (2). 62–7. in Russian.
7. Hirieva P.M. Optimization of management tactics for women of reproductive age with intrauterine synechiae [dissertation]. Moscow. National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov. 2018. in Russian.
8. Orazov M.R., Mikhaleva L.M., Ismailzade S.Ya., et al. Intrauterine synechiae and chronic endometritis – is there a causal relationship? Ginekologiya. 24 (2). 144–49. in Russian.
9. Siferih M., Gebre T., Hunduma F., et al. Review of Asherman syndrome and its hysteroscopic treatment outcomes: experience in a low-resource setting. BMC Womens Health. 2024. 7. 24 (1). 99.
10. Shchukina N.A., Buyanova S.N., Babunashvili E.L., Kashchuk M.G. Intrauterine synechiae after myomectomy. Diagnosis, treatment, prevention. Rossiyskiy vestnik akushera-ginekologa. 2021. 21 (2). 26–32. in Russian.
11. Vancaillie T., Chan K., Liu J., Deans R., Howard E. Asherman syndrome: Audit of a single-operator cohort of 423 cases. Aust. N. Z. J. Obstet. Gynaecol. 2020. 60. 4. 574 –78.
12. Schukina N.A., Scherbatykh M.G., Babunashvili E.L., et al. Intrauterine synechiae after myomectomy. Akusherstvo i Ginekologiya. 2023. 6. 134–40. in Russian.
13. Makarenko T.A., Nikiforova D.E., Ul'yanova I.O. Intrauterine synechiae: features of surgical treatment and prevention of relapses. Meditsinskiy sovet. 2018. 7. 146–51. in Russian.
14. Khirieva P.M., Kuznetsova M.V., Bystritsky A.A., et al. Investigation of the gene mRNA level in the endometrial tissue of reproductive-aged women with intrauterine synechiae. Akusherstvo i Ginekologiya. 2018. 2. 56–64. in Russian.
15. Fritsch H. Ein fall von volligen Schwund der Gebarmutterhohle nach Auskratzung. Zentrabi. Gynaekol. 1894. 18. 1337-1339.
16. Orazov M.R., Radzinskiy V.E., Mikhaleva L.M., et al. The effectiveness of the treatment of intrauterine synechiae in women of reproductive age. A clinical case. Ginekologiya. 2021. 23 (5): 435–40. in Russian.
17. Ayasa L.A., Abdallah J.O., Saifi M., Wafi A. A Case Report of Asherman's Syndrome With Abnormal Placenta Implantation (Intrauterine Adhesion). Cureus. 2023. 2. 15 (6). 9878.
18. Guziy E.A. Miscarriage of pregnancy, the causes of which were isthmic-cervical insufficiency and Ascherman syndrome. Zdorov'e i obrazovanie v XXI veke. 2018. 20 (8). 21–4. in Russian.
19. Тikhomirov A.L., Sarsania S.I., Tyskayev K.S., Yudina T.A. Prevention of recurrent endometrial pathology. Meditsinskiy sovet. 2019. 7. 21–6. in Russian.
20. Bender R.A., Özcan C., Akar B. Comparison of the localization of intrauterine adhesions in pregnant and infertile women. Turk. J. Obstet. Gynecol. 2022. 23. 19 (3). 195–200.
21. Dzhibladze T.A., Svidinskaya E.A., Bortsvadze Sh.N., et al. Intrauterine synechiae and Ascherman syndrome: an integrated approach to diagnosis and treatment. Voprosy ginekologii, akusherstva i perinatologii. 2021. 20 (5). 43–50. in Russian.
22. Khan Z. Etiology, Risk Factors, and Management of Asherman Syndrome. Obstet. Gynecol. 2023. 1. 142 (3). 543–54.
23. Maksimova T.A., Cherkasova A.L., Dzhibladze T.A., et al. Minimally invasive interventions in the diagnosis and treatment of intrauterine pathology in women with infertility. Voprosy ginekologii, akusherstva i perinatologii. 2018. 17. 27–32. in Russian.
24. Doroftei B., Dabuleanu A.M., Ilie O.D. Mini-Review of the New Therapeutic Possibilities in Asherman Syndrome-Where Are We after One Hundred and Twenty-Six Years? Diagnostics (Basel). 2020. 17. 10 (9). 706.
25. Di Guardo F., Della Corte L., Vilos G., et al. Evaluation and treatment of infertile women with Asherman syndrome: an updated review focusing on the role of hysteroscopy. Reprod. Biomed. Online. 2020. 41 (1). 55–61.
26. Bortsvadze Sh. N., Svidinskaya E.A., Dzhibladze T.A., Zuev V. M., Khokhlova I. D. Ultrasound monitoring of hysteroscopic laser ablation in case of uterine adhesions. Rossiyskiy vestnik akushera-ginekologa. 2021. 21 (1). 69–73. in Russian.
27. Mudueva S.R., Zakharova P.V., Kurelov M.A., Kaitova Z.S. Methods of treatment of Ascherman syndrome to restore reproductive function. Medical & pharmaceutical jornal «Pulse». 2022. 24 (5). 68–72. in Russian.
28. Zheng F., Zhu B., Liu Y., Wang R., Cui Y. Meta-analysis of the use of amniotic membrane to prevent recurrence of intrauterine adhesion after hysteroscopic adhesiolysis. Int. J. Gynaecol. Obstet. 2018. 143 (2). 145–9.
29. Chung J.P.W., Law T.S.M., Ng K., Ip P.N.P., Li T.C. Intrauterine adhesion in ultrasound-guided manual vacuum aspiration (USG-MVA) versus electric vacuum aspiration (EVA): a randomised controlled trial. BMC Pregnancy Childbirth. 2024. 14. 24 (1). 135.
30. Hanstede M.F., van Stralen K.J., Molkenboer J.F.M., Weersema S. Hormonal support in women with Asherman syndrome does not lead to better outcomes: A randomized trial. Reprod. Med. Biol. 2023. 29. 22 (1). 12526.
31. Glukhov E.Yu., Dikke G.B., Neff E.I., Glukhova V.E., Berezina D.A. The experience of using complex therapy in the treatment of patients with Ascherman syndrome. Farmateka. 2021. 6. 64–70. in Russian.
32. Dreisler E., Kjer J.J. Asherman's syndrome: current perspectives on diagnosis and management. Int. J. Womens Health. 2019. 20 (11). 191–8.
33. Martynov S.A., Adamyan L.V., Arakelyan A.S., Fedorova T.A., Bystry O.A. The possibilities of using platelet-enriched autoplasm in the complex treatment of patients with intrauterine synechiae. Ginekologiya. 2021. 23 (3). 250–4. in Russian.
34. Liu F., Hu S., Wang S., Cheng K. Cell and biomaterial-based approaches to uterus regeneration. Regen. Biomater. 6 (3). 141–8.
35. Kirakosyan E.V., Lyundup A.V., Aleksandrov L.S., et al. Prospects for the use of cellular technologies in the treatment of female infertility. Voprosy ginekologii, akusherstva i perinatologii. 2020. 19 (4). 146–58. in Russian.
36. Sukhikh G.T., Chernukha G.E., Tabeeva G.I., Goryunov K.V., Silachev D.N. Modern possibilities of cell therapy of Ascherman syndrome. Akusherstvo i Ginekologiya. 2018. 5. 20–8. in Russian.
37. Saribas G.S., Ozogul C., Tiryaki M., Pinarli F.A., Kilic S.H. Effects of uterus derived mesenchymal stem cells and their exosomes on asherman's syndrome. Acta Histochem. 2020. 122 (1). 51465.
38. Poltavtseva R.A., Pul'ver A.Yu., Pul'ver N.A., Svershchevskaya E.V. Development of biotissue based on thermosensitive biogel for the treatment of Ascherman syndrome. Materialy V natsional'nogo kongressa regenerativnoy meditsiny. Geny &. 2022. 17 (3). 182. in Russian.
39. Liu H., Xu Y., Yi N. Efficacy and Safety of Hyaluronic Acid Gel for the Prevention of Intrauterine Adhesion: A Meta-Analysis of Randomized Clinical Trials. Gynecol. Obstet. Invest. 2018. 83 (3). 227–33.
40. Shvetsova A.M., Ershov K. I., Korolev M. A., Madonov P.G. The results of experiments on the development of highly purified hyaluronate-endo-β-N-acetylhexosaminidase as a pharmaceutical substance for a medicinal product. Byulleten` medicinskoj nauki. 2023. 32(4). 68–80. in Russian.
Review
For citations:
Remneva O.V., Belnickaya O.A., Igitova M.B., Fadeeva N.I., Garanin S.F. ASCHERMAN SYNDROME: FROM ETIOLOGY TO PREVENTION. Transbaikalian Medical Bulletin. 2024;(2):122-134. (In Russ.) https://doi.org/10.52485/19986173_2024_2_122