CARDIOVASCULAR COMPLICATIONS DUE TO ABUSE OF SYNTHETIC CATHINONES
https://doi.org/10.52485/19986173_2025_3_191
Abstract
Justification/Relevance: a review of the literature is presented with a clinical example of poisoning with a mixture of psychotropic substances such as: 4-chloromethcathinone (clephedrone), alphapyrrolidinovalerophenone (a derivative of the narcotic drug N-methylephedrone), tetrahydrocannabinol.
About the Authors
D. S. Shilin
Chita State Medical Academy; City Clinical Hospital No 1
Russian Federation
Russian Federation
Shilin D.S., Candidate of Medical Sciences, anesthesiologist-resuscitator, assistant of the Department of Anesthesiology, Resuscitation and Intensive Care
39a Gorky St., Chita, 672000
8 Lenina St., Chita, 672039
A. A. Novikova
City Clinical Hospital No 1
Russian Federation
Russian Federation
Novikova A.A., 4th year student of the Faculty of Medicine
8 Lenina St., Chita, 672039
N. A. Yaroslavtseva
State Healthcare Institution «Transbaikal Regional Bureau of Forensic Medical Examination»
Russian Federation
Russian Federation
Yaroslavtseva N.A., Forensic physician of the Department of Forensic Medical Examination of Corpses
64 Matveeva St., Chita, 672038
A. A. Antip'eva
State Medical Institution "Zabaikalsky Regional Bureau of Forensic Medical Examination"
Russian Federation
Russian Federation
Antipyeva A.A., Forensic physician, first qualification category, Head of the Department of Forensic Medical Examination of Corpses of the State Medical Institution
64 Matveeva St., Chita, 672038
K. G. Shapovalov
Chita State Medical Academy; City Clinical Hospital No 1
Russian Federation
Russian Federation
Shapovalov K.G., Doctor of Medical Sciences, Professor, anesthesiologist-resuscitator, Head of the Department of Anesthesiology and Resuscitation
39a Gorky St., Chita, 672000
8 Lenina St., Chita, 672039
References
1. Silva B. et al. Khat, a cultural chewing drug: a toxicokinetic and toxicodynamic summary. Toxins. 2022. Т. 14. №. 2. С. 71.
2. Simmons S.J. et al. DARK classics in chemical neuroscience: cathinone-derived psychostimulants. ACS chemical neuroscience. 2018. Т. 9. №. 10. С. 2379–2394.
3. Groenewegen K.L. et al. Cardiotoxicity After Synthetic Cathinone Use; Two Cases, A Case Series and Scoping Review. Cardiovascular Toxicology. 2024. Т. 24. №. 3. С. 209–224.
4. Manthey J. et al. Public health monitoring of cannabis use in Europe: prevalence of use, cannabis potency, and treatment rates. The Lancet Regional Health–Europe. 2021. Т. 10.
5. Nóbrega L., Dinis-Oliveira R.J. The synthetic cathinone α-pyrrolidinovalerophenone (α-PVP): pharmacokinetic and pharmacodynamic clinical and forensic aspects. Drug metabolism reviews. 2018. Т. 50. №. 2. С. 125–139.
6. Ross E. A. et al. Psychoactive “bath salts” intoxication with methylenedioxypyrovalerone. The American journal of medicine. 2012. Т. 125. №. 9. С. 854–858.
7. Yurchenko R.А., Yurchenko L.V., et al. Recent trends in the field of identification of psychoactive substances. Issue 49 January 2024 (https://aipsin.com/journal/56/). Electronic edition WEB Aipsin (https://aipsin.com). In Russian.
8. Nugteren-van Lonkhuyzen J.J. et al. 3-Methylmethcathinone (3-MMC) poisonings: acute clinical toxicity and time trend between 2013 and 2021 in the Netherlands. Annals of emergency medicine. 2022. Т. 80. №. 3. С. 203–212.
9. Mead J., Parrott A. Mephedrone and MDMA: a comparative review. Brain research. 2020. Т. 1735. С. 146740.
10. Papaseit E. et al. Mephedrone concentrations in cases of clinical intoxication. Current pharmaceutical design. 2017. Т. 23. №. 36. С. 5511–5522.
11. Angoa-Pérez M., Anneken J.H., Kuhn D.M. Neurotoxicology of synthetic cathinone analogs. Neuropharmacology of New Psychoactive Substances (NPS) The Science Behind the Headlines. 2017. С. 209–230.
12. Groenewegen K.L. et al. Cardiotoxicity After Synthetic Cathinone Use; Two Cases, A Case Series and Scoping Review. Cardiovascular Toxicology. 2024. Т. 24. №. 3. С. 209–224.
13. Geta T. G. et al. Association of chronic khat chewing with blood pressure and predictors of hypertension among adults in Gurage Zone, Southern Ethiopia: a comparative study. Integrated blood pressure control. 2019. С. 33–42.
14. Tian M. et al. Fatal methanol poisoning with different clinical and autopsy findings: Case report and literature review. Legal Medicine. 2022. Т. 54. С. 101995.
15. Ali W. M. et al. Association of khat chewing with increased risk of stroke and death in patients presenting with acute coronary syndrome. Mayo Clinic Proceedings. Elsevier, 2010. Т. 85. №. 11. С. 974–980.
16. Bochkareva T.K. Nomenklatura narkoticheskikh sredstv i psikhotropnykh veshchestv, vyyavlennykh pri podtverzhdayushchikh khimiko-toksikologicheskikh issledovaniyakh v 2017-2019 godakh v GAUZ "Zabaykal'skiy Kraevoy Narkologicheskiy Dispanser". Aktual'nye problemy psikhiatrii i narkologii v sovremennykh usloviyakh. 2020. S. 21–23. In Russian.
17. Shilin D.S., Shil'nikov S.A., Bushina E.R. et al. Otravlenie metilovym spirtom. Zabaykal'skiy meditsinskiy vestnik. 2025; (1): 237–244. Available from: https://doi.org/10.52485/19986173_2025_1_237. In Russian.
18. Grifell M. et al. Patterns of use and toxicity of new para‐halogenated substituted cathinones: 4‐CMC (clephedrone), 4‐CEC (4‐chloroethcatinone) and 4‐BMC (brephedrone). Human Psychopharmacology: Clinical and Experimental. 2017. Т. 32. №. 3. С. e2621.
19. Patocka J. et al. Flakka: new dangerous synthetic cathinone on the drug scene. International journal of molecular sciences. 2020. Т. 21. №. 21. С. 81–85.
Review
For citations:
Shilin D.S., Novikova A.A., Yaroslavtseva N.A., Antip'eva A.A., Shapovalov K.G. CARDIOVASCULAR COMPLICATIONS DUE TO ABUSE OF SYNTHETIC CATHINONES. Transbaikalian Medical Bulletin. 2025;(3):191-199. (In Russ.) https://doi.org/10.52485/19986173_2025_3_191
Views:
13
Email this article 