CORRECTION OF CALCIUM AND PHOSPHATE IMBALANCE IN PEDIATRIC INTENSIVE CARE PRACTICE
https://doi.org/10.52485/19986173_2024_4_86
Abstract
Despite the high prevalence of calcium (Ca2+) and phosphate (P) imbalance in pediatric intensive care practice, this electrolyte disturbance is often overlooked because of its non-specific symptoms and the higher prevalence of imbalances involving other electrolytes (potassium, sodium, magnesium). The physiological role of Ca2+ and P makes them extremely important for supporting the body's major systems, and a significant fall or rise of the levels of these electrolytes can lead to decompensation of vital systems, increasing the risk of death in critically ill children. Many urgent conditions call for constant monitoring of Ca and P levels in blood serum for early detection of hypo- and hypercalcemia, as well as hypo- and hyperphosphatemia, because often no specific symptoms are present in these conditions. The amount of intensive therapy measures required in a child or adolescent with such an electrolyte imbalance is determined primarily by severity of the Ca2+ and P deficiency or toxicity, and by the presence of any background discase that triggers this electrolyte disorder. In an intensive care unit, the treatments of choice for severe hypocalcemia and hypophosphatemia are parenteral preparations of Ca2+ and P.
About the Authors
Yu. V. BykovRussian Federation
Bykov Y.V., Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology and Intensive Care
310 Mira St., Stavropol, Russia, 355017
A. N. Obedin
Russian Federation
Obedin A.N., Doctor of Medical Sciences, Head of the Department of Anesthesiology, Intensive Care
310 Mira St., Stavropol, Russia, 355017;
3/1 Semashko St.,Stavropol, Russia, 355002
O. V. Zinchenko
Russian Federation
Zinchenko O.V., Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology, Intensive Care
310 Mira St., Stavropol, Russia, 355017
A. A. Muravyeva
Russian Federation
Muravyeva A.A., Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology, Intensive Care
310 Mira St., Stavropol, Russia, 355017
I. V. Yatsuk
Russian Federation
Yatsuk I.V., Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology, Intensive Care
310 Mira St., Stavropol, Russia, 355017;
17 Tukhachevsky St., Stavropol, Russia, 355032
E. V. Volkov
Russian Federation
Volkov E.V., Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology, Intensive Care
310 Mira St., Stavropol, Russia, 355017;
1 Semashko St., Stavropol, Russia, 355002
V. V. Fischer
Russian Federation
Fischer V.V., Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology, Intensive Care
310 Mira St., Stavropol, Russia, 355017;
1 Lenin St., Stavropol, Russia, 356240
References
1. Anghel L., Manole C., Nechita A. et al. Calcium, Phosphorus and Magnesium Abnormalities Associated with COVID-19 Infection, and Beyond. Biomedicines. 2023. 11 (9). 2362. DOI: 10.3390/biomedicines11092362.
2. Shaker J.L., Deftos L. Calcium and Phosphate Homeostasis. Endotext [Internet]. 2023. Bookshelf ID: NBK279023.
3. Sun M., Wu X., Yu Y. et al. Disorders of Calcium and Phosphorus Metabolism and the Proteomics/ Metabolomics-Based Research. Front Cell Dev Biol. 2020. 8. 576110. DOI: 10.3389/fcell.2020.576110.
4. Thongprayoon C., Cheungpasitporn W., Chewcharat A. et al. Hospital mortality and long-term mortality among hospitalized patients with various admission serum ionized calcium levels. Postgrad Med. 2020. 132 (4). 385–390. DOI: 10.1080/00325481.2020.1728980
5. Hamroun A., Pekar J.D., Lionet A. et al. Ionized calcium: analytical challenges and clinical relevance. JLPM. 2020. 5. 1–16. DOI: 10.21037/jlpm-20-60.
6. Tinaw M. Disorders of Calcium Metabolism: Hypocalcemia and Hypercalcemia. Cureus. 2021. 13 (1). 12420. DOI: 10.7759/cureus.12420
7. Sadiq N.M., Patel G., Badireddy M. Hypercalcemia. StatPearls [Internet]. 2024. Bookshelf ID: NBK430714
8. Giuliano C.A., Perets V., Hijazi M. et al. Dose-response of intravenous calcium in the surgical intensive care unit. Int J Clin Pharm 2021. 43. 246–250. DOI: 10.1007/s11096-020-01145-7.
9. Zhao J., Liu M., Yu D. et al. Serum calcium and mortality in pediatric pneumonia patients admitted to the PICU: a retrospective cohort study. Sci Rep. 2024. 14 (1). 18683. DOI: 10.1038/s41598-024-69885-4.
10. Chonchol M., Smogorzewski M., Stubbs J., Yu A.S. Brenner & Rector's The Kidney. Vol. 11. Philadelphia, PA: Elsevier Inc; 2019. Disorders of calcium, magnesium, and phosphate balance; p. 613.
11. Melchers M., van Zanten A.R. Management of hypocalcaemia in the critically ill. Curr Opin Crit Care. 2023. 29 (4). 330–338. DOI: 10.1097/MCC.0000000000001059
12. Goyal A., Anastasopoulou C., Ngu M., Singh S. Hypocalcemia. StatPearls [Internet]. 2023. Bookshelf ID: NBK430912.
13. Bharill S., WuIn M. Brief: Hypocalcemia and Hypercalcemia in Children. Pediatr Rev. 2023. 44 (9). 533– 536. DOI: 10.1542/pir.2022-005578.
14. Vuralli D. Clinical Approach to Hypocalcemia in Newborn Period and Infancy: Who Should Be Treated? Int J Pediatr. 2019; 2019 : 4318075. DOI: 10.1155/2019/4318075.
15. He W., Huang L., Luo H. et al. The positive and negative effects of calcium supplementation on mortality in septic ICU patients depend on disease severity: a retrospective study from the MIMIC-III. Crit Care Res Pract 2022. 2022. 2520695. DOI: 10.1155/2022/2520695.
16. Kestenbaum B., Houillier P. Comprehensive Clinical Nephrology. Vol. 6. Philadelphia, PA: Elsevier Inc; 2018. Disorders of calcium, phosphate, and magnesium metabolism; pp. 124–141.
17. Kronstedt S., Roberts N., Ditzel R. et al. Hypocalcemia as a predictor of mortality and transfusion. A scoping review of hypocalcemia in trauma and hemostatic resuscitation. Transfusion. 2022. 62 (1). 158– 166. DOI: 10.1111/trf.16965
18. Catalano A., Chilà D., Bellone F. et al. Incidence of hypocalcemia and hypercalcemia in hospitalized patients: Is it changing? J Clin Transl Endocrinol. 2018. 13. 9-13. DOI: 10.1016/j.jcte.2018.05.004.
19. Zagzag J., Hu M.I., Fisher S.B. et al. Hypercalcemia and cancer: differential diagnosis and treatment. CA Cancer J Clin. 2018. 68. 377–386. DOI: 10.3322/caac.21489.
20. Renaghan A.D, Rosner M.H. Hypercalcemia: etiology and management. Nephrol Dial Transpl. 2018. 33. 549–551. DOI: 10.1093/ndt/gfy054.
21. Tonon C.R., Silva T.A, Pereira F.W. et al. A Review of Current Clinical Concepts in the Pathophysiology, Etiology, Diagnosis, and Management of Hypercalcemia. Med Sci Monit. 2022. 28. 935821. DOI: 10.12659/MSM.935821.
22. Reintam Blaser A., Gunst J., Ichai C. et al. Hypophosphatemia in critically ill adults and children - A systematic review. Clin Nutr. 2021. 40 (4). 1744–1754. DOI: 10.1016/j.clnu.2020.09.045.
23. Sharma S., Hashmi M.F., Kaur J., Castro D. Hypophosphatemia. StatPearls [Internet]. 2024. Bookshelf ID: NBK493172.
24. Vijaywargiya T., Maurya S., Mohapatra S. Phosphorus abnormalities in a paediatric intensive care unit in North India. Sri Lanka Journal of Child Health. 2023. 52 (4). 451–456. DOI: 10.4038/sljch.v52i4.10619
25. Koljonen L., Enlund-Cerullo M., Hauta-Alus H. et al. Phosphate Concentrations and Modifying Factors in Healthy Children From 12 to 24 Months of Age. J Clin Endocrinol Metab. 2021. 106 (10). 2865-2875. DOI: 10.1210/clinem/dgab495.
26. Berger M.M.,Appelberg O., Reintam-BlaserA. et al. ESICM-MEN section. Prevalence of hypophosphatemia in the ICU - Results of an international one-day point prevalence survey. Clin Nutr. 2021. 40 (5). 3615– 3621. DOI: 10.1016/j.clnu.2020.12.017.
27. Kalantar-Zadeh K., Ganz T., Trumbo H. et al. Parenteral iron therapy and phosphorus homeostasis: A review. Am J Hematol. 2021. 96 (5). 606–616. DOI: 10.1002/ajh.26100.
28. Akbaş Y., Koker A., Erkek N. Are we aware that hyperphosphatemia affects mortality and morbidity as much as hypophosphatemia in pediatric intensive care patients? Pediatr Endocrinol Rev. 2019. 17. 35–40. DOI: 10.17458/per.vol17.2019.
29. Veldscholte K., Veen M.A., Eveleens R.D. et al. Early hypophosphatemia in critically ill children and the effect of parenteral nutrition: A secondary analysis of the PEPaNIC RCT. Clinical nutritional. 2022. 41 (11). 2500-2508. DOI: 10.1016/j.clnu.2022.09.001.
30. Portales-Castillo I, Rieg I, Khalid S.B. et al. Physiopathology of Phosphate Disorders. Adv Kidney Dis Health. 2023; 30 (2) : 177–188. DOI: 10.1053/j.akdh.2022.12.011.
31. Florenzano P., Cipriani C., Roszko K.L. et al. Approach to patients with hypophosphataemia. Lancet Diabetes Endocrinol. 2020. 8. 163–174. DOI: 10.1016/S2213-8587(19)30426-7.
32. Uday S., Sakka S., Davies J.H. et al. Elemental formula associated hypophosphataemic rickets. Clin Nutr. 2019. 38 (5). 2246–2250. DOI: 10.1016/j.clnu.2018.09.028.
33. Zhou X., He J., Zhu D. et al. Relationship between serum phosphate and mortality in critically ill children receiving continuous renal replacement therapy. Front Pediatr. 2023. 11. 1129156. DOI: 10.3389/fped.2023.1129156.
34. Ahmed F.A., Begum M., Al Sharhan M.A. Spurious Hyperphosphatemia in Two Children With End-Stage Renal Disease: A Case Report. Cureus. 2024. 16 (3). 55818. DOI: 10.7759/cureus.55818.
35. Rout P., Jialal I. Hyperphosphatemia. StatPearls [Internet]. 2023. Bookshelf ID: NBK551586.
36. Zheng W.H., Yao Y., Zhou H. et al. Hyperphosphatemia and Outcomes in Critically Ill Patients: ASystematic Review and Meta-Analysis. Front Med (Lausanne). 2022. 9. 870637. DOI: 10.3389/fmed.2022.870637.
37. Lingappa L., Ichikawa S., Gray A.K. et al. An Unusual Combination of Neurological Manifestations and Sudden Vision Loss in a Child with Familial Hyperphosphatemic Tumoral Calcinosis. Ann Indian Acad Neurol. 2019. 22 (3). 327–331. DOI: 10.4103/aian.AIAN_191_18.
38. Rugg C., Bachler M., Kammerlander R. et al. ICU-Admission Hyperphosphataemia Is Related to Shock and Tissue Damage, Indicating Injury Severity and Mortality in Polytrauma Patients. Diagnostics (Basel). 2021. 11 (9). 1548. DOI: 10.3390/diagnostics11091548.
Review
For citations:
Bykov Yu.V., Obedin A.N., Zinchenko O.V., Muravyeva A.A., Yatsuk I.V., Volkov E.V., Fischer V.V. CORRECTION OF CALCIUM AND PHOSPHATE IMBALANCE IN PEDIATRIC INTENSIVE CARE PRACTICE. Transbaikalian Medical Bulletin. 2024;(4):86-98. (In Russ.) https://doi.org/10.52485/19986173_2024_4_86