NUTRITIONAL DISORDERS IN HIV-INFECTION COMPLICATED BY PNEUMONIA
https://doi.org/10.52485/19986173_2022_1_146
Abstract
The aim of the research is to study the changes of nutritional status in HIV-positive patients with bacterial pneumonia and the estimation of the traditional nutritional support methods effectiveness.
Methods. The research was made on the basis of Perm State Clinical Infectious Diseases Hospital in 2014 – 2018. It included clinical and laboratory data as well as the study of nutritional status in 92 HIV-positive patients with the stage of secondary diseases (4А, 4Б, 4В), progression phase in the absence of ART, with manifestations of pneumonia. Among them the first group were patients hospitalized in the intensive care unit, the second group was treated in a specialized department. On the 1st, 10th and 21st days an evaluation of the trophological status and BMI calculation, determination of the levels of total protein, albumin, transferrin in the blood serum, the absolute number of lymphocytes in the peripheral blood, basal metabolism (Harris-Benedict formula), and iron indices were made.
Results. In HIV-positive patients with bacterial pneumonia in both groups, the development of the visceral protein pool deficiency was observed: serum albumin and transferrin were reduced, their levels on admission corresponded to a moderate degree of protein deficiency. Subsequently, negative dynamics of the nutritional status and the correlation.
Conclusion. It is necessary to introduce methods of nutritional support into routine practice in HIV-positive patients with bacterial pneumonia.
About the Authors
V. V. Nikolenko
Academician Ye.A. Wagner Perm State Medical University
Russian Federation
Russian Federation
26 Petropavlovskaya str., Perm, 614990
I. N. Prelous
Academician Ye.A. Wagner Perm State Medical University
Russian Federation
Russian Federation
26 Petropavlovskaya str., Perm, 614990
A. M. Bubnov
Academician Ye.A. Wagner Perm State Medical University
Russian Federation
Russian Federation
26 Petropavlovskaya str., Perm, 614990
M. R. Minikeeva
Academician Ye.A. Wagner Perm State Medical University
Russian Federation
Russian Federation
26 Petropavlovskaya str., Perm, 614990
O. E. Mikova
Perm Regional Center for the Prevention and Control of AIDS and Infectious Diseases
Russian Federation
Russian Federation
Perm, 614088, Sviyazeva 21
References
1. [HIV infection and AIDS: national guidelines: 2 nd edition] ed. Pokrovsky V.V. M.: GEOTAR-Media, 2020. 686. in Russian.
2. Pokrovskiy V.V., Yurin O.G., Belyaeva V.V. Buravtsova E. V., Ermak T. N., Kravchenko A. V., Voronin E. E., Afonina L. Yu., Fomin Yu. A. Clinical diagnosis and treatment of HIV infection. M., 2003. 96. in Russian.
3. Cohen J., West A. B., Bini E. J. Infectious diarrhea in HIV. Gastroenterol Clin North Am. 2001. 30. 637–664. DOI:10.1016/S0889-8553(05)70203-X.
4. Nikolenko V.V., Vorob'eva N.N., Naumova L.M., Solodnikova E.A., Bondarenko V.V., Abrosimova O.V., Nagaenko A.V., Golikova E. V., Minikeeva M.R. Damage of the respiratory and nervous systems of Streptococcus pneumoniae in HIV-positive patients. Epidemiologiya i infektsionnye bolezni. 2013. 4. 23-27. DOI: 10.17816/EID40724. in Russian.
5. Perlenicek J.P., Graham N.M. He Y.D. Weight loss prior toclinical AIDS as predictor of survival. Multicenter AIDS cohort Study Investigators. Journal of Acquired Immunodeficiency Syndrome. 2011. 10. 579–585.
6. Allers K, Stahl-Hennig C, Fiedler T, Wibberg D, Hofmann J, Kunkel D, Moos V, Kreikemeyer B, Kalinowski J, Schneider T. The colonic mucosa-associated microbiome in SIV infection: shift towards Bacteroidetes coincides with mucosal CD4 + T cell depletion and enterocyte damage. Scientific Reports. 2020. 1. 10887. DOI: 10.1038/s41598-020-67843-4.
7. Venegas A A.G., Castaño L.A.M., Chaparro J.A.R. Approach to diarrhea in HIV patients. Rev Colomb Gastroenterol. 2018. 33 (2). 148-158. DOI: 10.22516/25007440.192
8. Shabert J.K., Wilmore D.W. Glutamine deficiency as a cause of human immunodeficiency virus wasting. Med. Hypotheses. 1996. 46. 252-256. DOI:10.1016/s0306-9877(96)90251-0.
9. Emerole K.Ch., Pokrovskaya A.V., Pilipenko V.I., Kozhevnikova G.M., Isakov V.A., Pokrovskiy V.V. Assessment of actual nutrition and body composition in patients with HIV infection. Infektsionnye bolezni. 2017. (15). 1. 5-9. DOI:10.20953/1729-92225-2017-1-5-9. in Russian.
10. Nikolenko V.V., Nikolenko A.V, Minikeeva M.R Study of changes in nutritional status in HIV-positive patients with pneumonia caused by Streptococcus pneumoniae. Permskiy meditsinskiy zhurnal. 2018. 4. 14-19. DOI: 10.17816/pmj35414-19. in Russian.
11. Semba R.D., Tang A.M. Micronutrients and the pathogenesis of human immunodeficiency virus infection. The British Journal of Nutrition. 1999. 81 (3). 181-189. DOI: 10.1017/s0007114599000379
12. Kanestri V.G., Kravchenko A.V., Deulina M.O. Antiretroviral therapy and its impact on lipid metabolism. Epidemiologiya i infektsionnye bolezni. 2011. 1. 44-48. DOI:10.17816/EID40578. in Russian.
13. Luft V.M., Afonchikov V.S., Dmitriev A.V., Erpuleva E.V., Lapitskiy A.V., Lekmanov A.U., Luft A.V., Nazarov V.I., Popova T.S., Rasnovskaya N.F., Sergeeva A.M., Tropskaya N.S., Trofimov P.A., Shestopalov A.E. Clinical Nutrition Guide. M.: ≪Art-Ekspress≫. 3-e izd. 2016. 492. in Russian.
14. Abdullaev R.Yu., Komissarova O.G, Gerasimov L.N. Markers of protein-energy malnutrition in patients with tuberculosis combined with HIV infection during treatment. Tuberculosis and lung diseases. 2018. 7. 39-45. DOI: 10.21292/2075-1230-2018-96-7-39-45 in Russian.
15. Koethe J.R., Heimburger D.C. Nutritional aspects of HIV-associated wasting in sub-Saharan Africa. Am J Clin. Nutr. 2010. 91 (4). 1138-1142 S. DOI:10.3945/ajcn.2010.28608D
16. Tang A.M., Forrester J. Weight Loss and Survival in HIV-Positive Patients in the Era of Highly Active Antiretroviral Therapy. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2002. 10. 366-373. DOI: 10.1097/00126334-200210010-00014
17. Kalantar-Zadeh K., Kleiner, M., Dunne, E., Ahern, K., Nelson, M., Koslowe, R., Luft, F.C. Total iron-binding capacity-estimated transferrin correlates with the nutritional subjective global assessment in haemodialysis patients. Am. J. Kidney Dis. 1998. 31. 263–272.
18. Nikolenko A.V, Leyderman I.N., Nikolenko V.V. Screening of Key Markers of Protein and Micronutrient Metabolism in ICU Patients with Acute Pathology of the Abdominal Organs. Vestnik intensivnoy terapii imeni A.I. Saltanova. 2019. 4. 81-87. DOI: 10.21320/1818-474X-2019-4-81-87. in Russian.
19. Jain S.; Gautam V.; Naseem S. Acute-phase proteins: As diagnostic tool. J. Pharm. Bioallied Sci. 2011. 1. 118–127.
20. Leiderman I.N., Gritsan A.I., Zabolotskikh I.B., Lomidze S.V., Mazurok V.A., Nekhaev I.V., Nikolaenko E.M., Nikolenko A.V., Polyakov I.V., Sytov A.V., Yaroshetskiy A.I. Perioperative nutritional support. Clinical guidelines. A.I. Saltanov. 2018. 3. 5-21. DOI: 10.21320/1818-474X-2018-3-5-21. in Russian.
21. Emerole K.Ch., Pokrovskaya A.V., Pilipenko V.I. Waste syndrome in patients with HIV infection. Therapeutic archive. 2016. 88 (5). 125-129. DOI 10.17116/terarkh2016885125-129 in Russian.
Review
For citations:
Nikolenko V.V., Prelous I.N., Bubnov A.M., Minikeeva M.R., Mikova O.E. NUTRITIONAL DISORDERS IN HIV-INFECTION COMPLICATED BY PNEUMONIA. Transbaikalian Medical Bulletin. 2022;(1):146-154. (In Russ.) https://doi.org/10.52485/19986173_2022_1_146
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