SYSTEMIC HEMODYNAMIC PARAMETERS IN PATIENTS WITH PNEUMONIA WITH A(H1N1) INFLUENZA

Abstract

Aims. To assess the indices of systemic hemodynamics in patients with severe pneumonia associated with influenza A(H1N1).

Materials and methods. 85 patients with pneumonia associated with influenza А(H1N1) were examined, 30 of them underwent invasive mechanical ventilation (group 1), 55- respiratory support in the form of O2 - therapy (flow 5-15 l/min) (group 2). The control group consisted of 15 healthy volunteers (group 3). The state of central hemodynamics was investigated by the method of volumetric compression oscillometry using the hardware-software complex "Globus".

Results. It was found that in patients with severe pneumonia with influenza A(H1N1), who are on invasive lung  ventilation,  the  indicators  of  systolic,  diastolic,  mean  hemodynamic  and  pulse  arterial  pressure increase. In the study of cardiac activity indicators, it was found that in patients of the 1st group, cardiac output and cardiac index increased, stroke volume and volumetric ejection velocity increased, the power of contractions of the left ventricle and energy consumption per 1 liter of cardiac output increased. In the study of vascular parameters in patients with pneumonia who are on invasive lung ventilation, an increase in pulse wave velocity, a decrease in compliance of the vascular system and a decrease in total peripheral vascular resistance were revealed.

Conclusion. Changes in systemic hemodynamic parameters were revealed in patients with severe pneumonia with  influenza  A(H1N1),  who  were  on  invasive  lung  ventilation,  which  reflects  the  degree  of  acute respiratory failure and is associated with the severity with her level.