Progressive supranuclear palsy. description of the clinical case
https://doi.org/10.52485/19986173_2023_1_182
Abstract
Progressive supranuclear palsy (PNP) (progressive supranuclear ophthalmoplegia, progressive supranuclear gaze paresis, Steele-Richardson-Olszewski disease) is a progressive neurodegenerative disease of the central nervous system that belongs to the group of taupathies. Taupathies are a group of diseases characterized by deposits of the tau protein in neurons and glial cells, which subsequently leads to their death. There are several isoforms of the tau protein, on the basis of which a classification of taupathies has been developed: there are 3R-taupathies (Pick's disease), and 4R-taupathies (PNP, corticobasal degeneration, etc.), there are also "mixed" taupathies (Alzheimer's disease). The article describes a rare variant of the course of PNP with corticobasal syndrome. The course of this disease was accompanied by polymorphic neurological symptoms in the form of various motor disorders, oculomotor disorders, disorders of the emotional-volitional sphere.
Keywords
Neurodegenerative diseases,
taupathies,
parkinsonism,
oculomotor disorders,
progressive supranuclear palsy
Supporting agencies: There was no financial support for writing the literature review.
About the Authors
A. Yu. Ma-Van-de
Chita State Medical Academy
Russian Federation
Russian Federation
672090; 39 A Gorkogo str.; Chita
Yu. A. Shirshov
Chita State Medical Academy
Russian Federation
Russian Federation
672090; 39 A Gorkogo str.; Chita
F. Yu. Belozertsev
Chita State Medical Academy
Russian Federation
Russian Federation
672090; 39 A Gorkogo str.; Chita
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Review
For citations:
Ma-Van-de A.Yu., Shirshov Yu.A., Belozertsev F.Yu. Progressive supranuclear palsy. description of the clinical case. Transbaikalian Medical Bulletin. 2023;(1):182-187. (In Russ.) https://doi.org/10.52485/19986173_2023_1_182
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