THE DEBUT OF RHEUMATOID ARTHRITIS IN OLD AGE: PREDICTORS AND PATHOMORPHOSIS OF THE DISEASE
https://doi.org/10.52485/19986173_2022_1_35
Abstract
The features of the onset rheumatoid arthritis in old age are discussed in the presented literature. The data of epidemiological studies of the adult population suffering from rheumatoid arthritis, the features of three clinical variants of the onset of rheumatoid arthritis in old age are presented. A comparative characteristic of the course of rheumatoid arthritis in different age groups is given. Immunological and genetic predictors of the onset of rheumatoid arthritis in old age presented. Previously, the debut was registered in mostly middle-aged people. In conclusion, it should be noted that the number of cases of rheumatoid arthritis in old age is increasing, which makes further research in this area relevant.
About the Authors
A. A. BurdinskayaRussian Federation
11 Gorbunov str., Chita, 672000
T. A. Aksenova
Russian Federation
39a Gorky str., Chita, 672000
V. V. Gorbunov
Russian Federation
39a Gorky str., Chita, 672000
S. Yu. Tsarenok
Russian Federation
39a Gorky str., Chita, 672000
K. E. Belomestnova
Russian Federation
39a Gorky str., Chita, 672000
References
1. Guseva I.A., Kuchikhina E.L., Demidova N.V., Avdeeva A.S., Soroka N.E., Abramov D.D., Cherkasova M.V., Samarkina E.Yu., Karateev D.E. Molecular genetic testing of ADC-positive patients with rheumatoid arthritis with high inflammatory activity of the disease. Nauchno-prakticheskaya revmatologiya. 2018. 56 (1). 28-32. in Russian.
2. Smolen J.S., Aletaha D., Mclnnes I.B. Rheumatoid arthritis. Lancet. 2016. 388. 2023-2038. DOI 10.1016/S01406736(16)30173-8.
3. Sinyachenko O.V., Pasieshvili L.M. Rheumatoid arthritis: definition, clinical and pathogenetic aspects. Vostochno-Evropeyskiy zhurnal vnutrenney i semeynoy meditsiny. 2018. 1. 4-15. in Russian.
4. Nasonov E.L. National guidelines. Reumatology. M.: GEOTAR-Media. 2017. 434. ISBN 978-5-9704-4261-6. in Russian.
5. Dydykina I.S., Kozhevnikova P.O. Study of local and generalized bone loss in patients with rheumatoid arthritis. Nauchno-prakticheskaya revmatologiya. 2019. 57(3). 328-332. in Russian.
6. Balabanova R.M., Kaptaeva A.K. Features of the clinical picture and treatment of rheumatoid arthritis in the elderly. Consilium medicum. 2016. 12. 12-18. in Russian.
7. Kozhevnikova P.O., Dydykina I.S. Late onset of rheumatoid arthritis in the elderly: features of the course of the disease. Effektivnaya farmakoterapiya. 2019. 15(400). 20-24. DOI 10.33978/2307-3586-2019-15-40-20-24. in Russian.
8. Smolen J.S., Aletaha D., McInnes I. B. Rheumatoid arthritis. Lancet. 2016. 388 (10055). 2023-2038. DOI 10.1016/S0140-6736(16)30173-8.
9. Krams T., Ruyssen-Witrand A., Nigon D., Degboe Y., Tobon G., Fautrel B., Berenbaum F., Cantagrel A., Constantin A. Effects of age at rheumatoid arthritis onset on clinical, radiographic, and functional outcomes: The ESPOIR cohort. Joint Bone Spine. 2016. 83 (5). 511-515. DOI 10.1016/j.Jbspin.2015.09.010.
10. Filimonova O.G., Chicherina E.N., Betekhtina S.N. The debut of rheumatoid arthritis in old age - difficulties of diagnosis and treatment: a clinical case. Farmateka. 2018. 14 (367). 67-71. in Russian.
11. Tan T.C., Gao X., Thong B.Y. et al. Comparison of elderly- and young-onset rheumatoid arthritis in an Asian cohort // Int. J. Rheum. Dis. 2017. Vol. 20. 6. 737–745.
12. Kobak S. An autumn tale: geriatric rheumatoid arthritis. Ther Adv Musculoskelet Dis. 2018. 10 (1). 3-11. DOI 10.1177/1759720X17740075.
13. Martusevich N.A. Rheumatoid arthritis in the elderly. Retsept. 2011. 3 (77). 99-106. in Russian.
14. Nasonov E.L. Problems of immunopathology of rheumatoid arthritis: the evolution of the disease. Nauchno-prakticheskaya revmatologiya. 2017. 55 (3). 277-284. in Russian.
15. Novikov A.A., Aleksandrova E.N., Diatroptova M.A., Nasonov E.L. The role of cytokines in the pathogenesis of rheumatoid arthritis. Nauchno-prakticheskaya revmatologiya. 2010. 2. 71-82. in Russian.
16. Catrina A.I., Svensson C.I., Malmstrom V., Schett G., Klareskog L. Mechanism leading from systemic autoimmunity to joint-specific disease in rheumatoid arrhritis. Nat. Rev. Immunol. 2017. 12 (2). 79-86. DOI 10.1038/nrrheum.2016.200.
17. Raskina T.A., Malyshenko O.S., Pankratova S.Yu., Fanaskov V.B., Letaeva M.V. Rheumatoid arthritis in elderly patients. Sovremennaya revmatologiya. 2017. 11 (1). 33-37. DOI 10.14412/1996-7012-2017-1-33-37. in Russian.
18. Satybaldyev A.M., Demidova N.V., Gridneva G.I., Nikishina N.Yu., Gerasimova E.V., Gukasyan D.A., Kasumova K.A., Luchikhina E.L., Misiyuk A.S., Oskilko T.G., Rumyantseva O.A., Zlepko E.A., Tyurina L.N., Fedorenko E.V., Shornikova N.V., Nasonov E.L. Clinical characteristics of three cohorts of early rheumatoid arthritis with late onset (aged 50 years and older). Generalization of 40 years of experience. Nauchno-prakticheskaya revmatologiya. 2020. 58 (2). 140-146. DOI 10.14412/1995-4484-2020-140-146. in Russian.
19. Konenkov V.I., Prokop'ev V.F., Shevchenko A.V., Chernyavskiy A.M., Karas'kov A.M. Age and sex dynamics of the structure of cytokine gene networks of the Russian population. Vestnik Rossiyskoy akademii meditsinskikh nauk. 2013. 9. 15-21. in Russian
20. Zanin S.A., Onishchuk V.V., Kade A.Kh., Kadomtsev D.V., Pasechnikova E.A. "Cytokine storm" in the pathogenesis of rheumatoid arthritis and deforming osteoarthritis of large joints. Sovremennye problemy nauki i obrazovaniya. 2017. 3. 9. in Russian
21. Baymukhamedov Ch. Rheumatoid arthritis in the elderly: the view of a practical rheumatologist. Nauchno-prakticheskaya revmatologiya. 2020. 54 (4). 447-450. in Russian
22. Vakhlevskiy V.V., Tyrenko V.V., Svinitskaya I.S., Kryukov E.V. Features of the course of rheumatic diseases against the background of a new coronavirus infection. RMZh. Meditsinskoe obozrenie. 2021. 5 (2). 84-88. DOI 10.32364/2587-6821-2021-5-2-84-88. in Russian
23. Kassina D.V., Vasilenko I.A., Gur'ev A.S., Volkov A.Yu., Metelin V.B. Neutrophil extracellular traps: significance for diagnosis and prognosis of COVID-19. Al'namakh klinicheskoy meditsiny. 2020. 48 (Special issue 1). 43-50. in Russian.
24. Brinkmann V. Neutrophil Extracellular Traps in the Second Decade. J. Innate Immun. 2018. 10. 414-421. DOI 10.1159/000489829.
25. Bedina S.A., Trofimenko A.S., Mamus M.A., Tikhomirova E.A., Mozgovaya E.E, Spitsina S.S., Devyataeva M.N. Formation of extracellular neutrophil traps in patients with rheumatoid arthritis. Sovremennye problemy nauki i obrazovaniya. 2020. 2. 12-15. in Russian
26. Konenkov V.I., Prokop'ev V.F., Shevchenko A.V., Korolev I.A. Immunogenetic criteria for predicting the development of joint diseases of various nature. Klinicheskaya meditsina. 2020. 98 (1). 43-48. in Russian.
27. Suslova T.A., Burmistrova A.L., Khromova E.B., Stashkevich D.S., Deval'd I.V., Isakanova A.O., Boldyreva M.N., Alekseev L.P. Genetic predisposition to rheumatoid arthritis: the role of HLA Class II genes and haplotypes. Immunologiya. 2008. 29 (3). 137-140. in Russian.
28. Kuzhir T.D. Polygenic nature of rheumatoid arthritis. Institut genetiki i tsitologii Natsional'noy akademii nauk Belorusi. 2019. 17 (4). 77-90. in Russian.
29. Stashkevich D.S., Khromova E.B., Deval'd I.V., Khodus E.A., Burmistrova A.L. Expanded haplotypes based on rare single nucleotide polymorphisms TNF A and HLA DRB1 in association with rheumatoid arthritis. Rossiyskiy immunologicheskiy zhurnal. 2021. 24 (4). 555-562. in Russian.
30. Raychaudhuri S., Sandor C., Stahl Е.A., Freundenberg J., Lee H.S., Jia X., Alfredsson L., Padyukov L., Klareskog L., Worthington J., Siminovitch K.A., Bae S.C., Plenge R.M., Gregersen P.K., de Bakker P.I. Five amino acids in there HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat. Genet. 2012. 44 (3). 291-296.
31. Nikulina S.Yu., Chernova A.A., Bol'shakova T.Yu., Fok Yu.V., Orlova N.M. Genes of predisposition to rheumatoid arthritis. Sibirskoe meditsinskoe obozrenie. 2014. 3.11-19. in Russian.
32. Danilko K.V., Nazarova L.M., Khabibullina R.R., Khayrullina R.R., Slesarenko L.S., Mutalova E.G., Viktorova T.V. IL 10, CTLA gene polymorphism and predisposition to rheumatoid arthritis. Nauchnyy rezul'tat. Meditsina i farmatsiya. 2018. 4 (2). 18-25. in Russian.
Review
For citations:
Burdinskaya A.A., Aksenova T.A., Gorbunov V.V., Tsarenok S.Yu., Belomestnova K.E. THE DEBUT OF RHEUMATOID ARTHRITIS IN OLD AGE: PREDICTORS AND PATHOMORPHOSIS OF THE DISEASE. Transbaikalian Medical Bulletin. 2022;(1):35-43. (In Russ.) https://doi.org/10.52485/19986173_2022_1_35