Interleukin-4 gene promoter polymorphism (C589T) and its influence on lymphocyte platelet adhesion and interleukin 4 concentration in blood of patients with influenza A(H3N2)
https://doi.org/10.52485/19986173_2022_4_42
Abstract
Aim was to study of the lymphocyte-platelet adhesion function and interleukin 4 concentration in blood of patients with influenza A(H3N2) depending on polymorphic variants of the IL-4 gene promoter (C589T).
Methods. The study was performed in 89 patients with influenza A(H3N2) and 96 healthy residents.
Results. It was found that the chance of developing influenza A(H3N2) increases in persons carrying the allele T (OR=2,37 [CI95%: 1,50-3,74]) (p=0,0002), heterozygous C/T variant (OR=1,88 [CI95%: 1,03-3,42]) and homozygous T/T genotype (OR=3,04 [CI95%: 1,12-8,23]) of the IL-4 gene promoter (C589T) (p=0,001). Among influenza A(H3N2) patients, the C/C homozygous carriers had the lowest concentration of IL-4, while the highest concentration was found in the carriers of the T/T variants. Carriers of the C/C genotype of the IL-4 gene promoter (C589T) have the highest ability for lymphocytic-platelet adhesion in influenza A (H3N2).
Conclusion. Indicators of the function of lymphocyte-platelet adhesion and interleukin 4 concentration in blood of patients with influenza A(H3N2) depend on the carriage of genotypes of the IL-4 gene promoter polymorphism (C589T).
About the Authors
A. S. Emelyanov
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky street, Chita, 672000
G. A. Chuprova
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky street, Chita, 672000
A. N. Emelyanova
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky street, Chita, 672000
Yu. A. Vitkovsky
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky street, Chita, 672000
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Review
For citations:
Emelyanov A.S., Chuprova G.A., Emelyanova A.N., Vitkovsky Yu.A. Interleukin-4 gene promoter polymorphism (C589T) and its influence on lymphocyte platelet adhesion and interleukin 4 concentration in blood of patients with influenza A(H3N2). Transbaikalian Medical Bulletin. 2022;(4):42-49. (In Russ.) https://doi.org/10.52485/19986173_2022_4_42
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