MARKERS OF ENDOTHELIAL DYSFUNCTION IN HYPOTHYROIDISM: REVIEW OF LITERATURE
https://doi.org/10.52485/19986173_2021_3_70
Abstract
The review summarizes literature data on endothelial dysfunction in hypothyroidism. There are presented materials on action of nitric oxide on vascular endothelium and on methods for determination of endothelial dysfunction by invasive and non-invasive methods. Data on the effect of thyroid function on the endothelium are summarized, in particular, issues of endothelium-dependent vasodilation in subclinical hypothyroidism are considered.
About the Authors
N. O. Grin'
Chita State Medical Academy
Russian Federation
Russian Federation
39A Gorky St, Chita, 672000
O. V. Serebryakova
Chita State Medical Academy
Russian Federation
Russian Federation
39A Gorky St, Chita, 672000
D. M. Serkin
Chita State Medical Academy
Russian Federation
Russian Federation
39A Gorky St, Chita, 672000
References
1. Vasina L.V., Petrishchev N.N., Vlasov T.D. Endothelial dysfunction and its main markers. Regional blood circulation and microcirculation. 2017. 16. 1. 4–15. in Russian.
2. Vorob'eva E.N., Vorob'ev R.I., Sharlaeva E.A., Fomicheva M.L., Sokolova G.G., Kazyzaeva A.S., Batanina I.A. Endothelial dysfunction in cardiovascular diseases: risk factors, methods of diagnosis and correction. Acta Biologica Sibirica. 2016. 2. 1. 21-40. DOI: 10.17116/jnevro201711741107-111. in Russian.
3. Mel'nikova Yu.S., Makarova T.P. Endothelial dysfunction as a central link in the pathogenesis of chronic diseases. Kazan Medical Journal. 2015. 96. 4. 659- 665. DOI: 10.17750/kmj2015-659. in Russian.
4. Fateeva V.V., Vorob'eva O.V. Markers of endothelial dysfunction in chronic cerebral ischemia. Journal of Neurology and Psychiatry. 2017. 4. 107-111. in Russian.
5. Hosseini S.M., Bakhtyari E.K., Heshmat-Ghahdarijani K., Khalili N. Evaluation of endothelial function in exogenous subclinical hyperthyroidism and the effect of treatment. Adv Biomed Res. 2016 Nov 28. 5. 173. doi: 10.4103/2277-9175.194800.
6. Daiber A., Steven S., Webe A., Shuvaev V.V., Muzykantov V.R., Laher I., Li H., Lamas S., Münzel T. Targeting vascular (endothelial) dysfunction. British J Pharm. 2017. 174. 1591– 1619.
7. Storch A.S., de Mattos J.D., Alves R., Galdino I. dos S., Rocha H.N.M. Methods of Endothelial Function Assessment: Description and Applications. Int. J. Cardiovasc Sci. 2017. 30 (3). 262-273.
8. Tarasov A.A., Reznikova E.A., Davydov S.I., Bochkareva O.I., Babaeva A.R. Clinical and prognostic significance of markers of endothelial dysfunction in atherosclerosis-associated vascular lesions. Medical alphabet. 2016. 3. 30 (293). 5-11. in Russian.
9. Yusupov D.M. The role of endothelial dysfunction in the development of cardiovascular diseases. Scientific observer. 2016. 11 (71). 52-54. in Russian.
10. Vanhoutte P.M, Shimokawa H., Feletou M., Tang E.H. Endothelial dysfunction and vascular disease - a 30th anniversary update. Acta Physiol (Oxf). 2017 Jan. 219(1). 22-96. doi: 10.1111/apha.12646.
11. Areas G.P.T., Mazzuco A., Caruso F.R., Jaenisch R.B., Cabiddu R., Phillips S.A., Arena R., Borghi-Silva A. Flow-mediated dilation and heart failure: a review with implications to physical rehabilitation. Heart Fail Rev. 2019 Jan. 24(1). 69-80. doi: 10.1007/s10741-018-9719-7.
12. Afonas'eva T.M. Endothelial dysfunction. Early diagnosis opportunities. Journal of Scientific Articles Health and Education in the XXI Century.2016. 18. 11. 101-104. in Russian.
13. Sagaidachnyi A.A. Reactive hyperemia test: methods of analysis, mechanisms of reaction and prospects. Regional hemodynamics and microcirculation. 2018. 17(3). 5–22. doi: 10.24884/1682-6655-2018-17-3-5-22 in Russian.
14. Stepanova T.V., Ivanov A.N., Popykhova E.B., Lagutina D.D. Endothelial dysfunction and its markers. Eurasian Scientific Association.2018. 11-2 (45). 120-123. in Russian.
15. Fatenkov O.V., Simerzin V.V., Gagloeva I.V., Galkina M.A., Panisheva Ya.A., Krasovskaya M.A., Sytdykov I.Kh., Popova Ya.O. Endothelial dysfunction as a predictor of subclinical and overt atherosclerosis. Science and innovation in medicine. 2018. 3 (11). 39-46. in Russian.
16. Pokrovskiy A.V., Kul'bak V.A., Fedorov E.E. Endothelial dysfunction as a marker of complications in vascular surgery. High-tech medicine. 2017. 4 (4). 12-20. in Russian.
17. Raitakari O., Clermajer D. Testing for endothelial dysfunction. Ann Med. 2000. 32(5). 293-304.
18. Pizov A.V., Pizov N.A., Skachkova O.A., Pizova N.V. Endothelial dysfunction as an early predictor of atherosclerosis. Medical alphabet. 2019. 4. 35 (410). 28-33. in Russian.
19. Oikonomou E., Siasos G., Tsigkou V., Bletsa E., Panoilia M.E., Oikonomou I.N., Simanidis I., Spinou M., Papastavrou A., Kokosias G., Zaromitidou M., Stampouloglou P., Spartalis M., Vavuranakis M., Stefanadis C., Papavassiliou A.G., Tousoulis D. Coronary Artery Disease and Endothelial Dysfunction: Novel Diagnostic and Therapeutic Approaches. Curr Med Chem. 2020. 27(7). 1052-1080. doi: 10.2174/0929867326666190830103219.
20. Anderson T.J, Phillips S.A. Assessment and prognosis of peripheral artery measures of vascular function. Prog Cardiovasc Dis. 2015 Mar-Apr. 57(5). 497-509. doi: 10.1016/j.pcad.2014.11.005.
21. Tremblay J.C, Pyke K.E. Flow-mediated dilation stimulated by sustained increases in shear stress: a useful tool for assessing endothelial function in humans? Am J Physiol Heart Circ Physiol. 2018 Mar 1. 314(3). 508-520. doi: 10.1152/ajpheart.00534.2017.
22. Hudgins L.C., Annavajjhala V., Kovanlikaya A., Frank M.D., Solomon A., Parker T.S., Cooper R.S. Non-invasive assessment of endothelial function in children with obesity and lipid disorders. Cardiol Young. 2016 Mar. 26(3). 532-8. doi: 10.1017/S1047951115000657.
23. Zaytsev D.N. Pathogenesis of cardiovascular disorders in chronic prostatitis [dissertation]. Chita. Chita State Medical Academy. 2013. in Russian.
24. Delitala A.P., Scuteri A., Maioli M., Mangatia P., Vilardi L., Erre G.L. Subclinical hypothyroidism and cardiovascular risk factors. Minerva Med. 2019 Dec. 110(6). 530-545. doi: 10.23736/S0026-4806.19.06292-X.
25. Ahmadi N., Ahmadi F., Sadiqi M., Ziemnicka K., Minczykowski A. Thyroid gland dysfunction and its effect on the cardiovascular system: a comprehensive review of the literature. Endokrynol Pol. 2020. 71(5). 466-478. doi: 10.5603/EP.a2020.0052.
26. Razvi S., Jabbar A., Pingitore A., Danzi S., Biondi B., Klein I., Peeters R., Zaman A., Iervasi G. Thyroid Hormones and Cardiovascular Function and Diseases. J Am Coll Cardiol. 2018 Apr 24. 71(16). 1781-1796. doi: 10.1016/j.jacc.2018.02.045.
27. Mullur R., Liu Y.Y., Brent G.A. Thyroid hormone regulation of metabolism. Physiol Rev. 2014 Apr. 94(2). 355-82. doi: 10.1152/physrev.00030.2013.
28. Danzi S., Klein I. Thyroid disease and the cardiovascular system. Endocrinol Metab Clin North Am. 2014 Jun. 43(2). 517-28. doi: 10.1016/j.ecl.2014.02.005.
29. Biondi B., Cappola A.R., Cooper D.S. Subclinical Hypothyroidism: A Review. JAMA. 2019 Jul 9. 322(2). 153-160. doi: 10.1001/jama.2019.9052.
30. Khan R., Sikanderkhel S., Gui J., Adeniyi A.R., O'Dell K., Erickson M., Malpartida J., Mufti Z., Khan T., Mufti H., Al-Adwan S.A., Alvarez D., Davis J., Pendley J., Patel D. Thyroid and Cardiovascular Disease: A Focused Review on the Impact of Hyperthyroidism in Heart Failure. Cardiol Res. 2020 Apr. 11(2). 68-75. doi: 10.14740/cr1034.
31. Sellitti D.F., Dennison D., Akamizu T., Kohn L.D., Koshiyama H. Thyrotropin regulation of cyclic adenosine monophosphate production in human coronary artery smooth muscle cells. Thyroid. 2000. 10. 219-25. doi: 10.1089/thy.2000.10.219. PMID: 10779136.
32. Rajagopalan V., Gerdes A.M. Role of thyroid hormones in ventricular remodeling. Curr Heart Fail Rep. 2015 Apr. 12(2). 141-9. doi: 10.1007/s11897-014-0246-0. PMID: 25492377.
33. Lozano-Cuenca J., López-Canales O.A., Aguilar-Carrasco J.C., Villagrana-Zesati J.R., LópezMayorga R.M., Castillo-Henkel E.F., López-Canales J.S. Pharmacological study of the mechanisms involved in the vasodilator effect produced by the acute application of triiodothyronine to rat aortic rings. Braz J Med Biol Res. 2016 Jul 25 49(8) 5304. doi: 10.1590/1414-431X20165304.
34. Hak A.E., Pols H.A., Visser T.J., Drexhage H.A., Hofman A., Witteman J.C. Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: the Rotterdam Study. Ann Intern Med. 2000 Feb 15. 132(4). 270-278. doi: 10.7326/0003-4819-132-4-200002150-00004.
35. Volkova I.R. Subclinical hypothyroidism as a factor of cardiovascular risk in patients with ischemic heart disease [dissertation]. Saint Petersburg. Academician I.P. Pavlov First St. Petersburg State Medical University. 2015. In Russian.
36. Kang J., Kim H.L., Seo J.B., Lee J.Y., Moon M.K., Chung W.Y. Endothelial function estimated by digital reactive hyperemia in patients with atherosclerotic risk factors or coronary artery disease. Heart Vessels. 2018 Jul.33(7). 706-712. doi: 10.1007/s00380-018-1118-4.
37. Omidi N., Khorgami M., Tajrishi F.Z., Seyedhoseinpour A., Pasbakhsh P.. The Role of Thyroid Diseases and their Medications in Cardiovascular Disorders: A Review of the Literature. Curr Cardiol Rev. 2020. 16(2). 103-116. doi: 10.2174/1573403X15666191008111238.
38. Sue L.Y., Leung A.M. Levothyroxine for the Treatment of Subclinical Hypothyroidism and Cardiovascular Disease. Front Endocrinol (Lausanne). 2020 Oct 21. 11. 591588. doi: 10.3389/fendo.2020.591588.
39. Razvi S., Jabbar A., Pingitore A., Danzi S., Biondi B., Klein I., Peeters R., Zaman A., Iervasi G. Thyroid Hormones and Cardiovascular Function and Diseases. J Am Coll Cardiol. 2018 Apr 24. 71(16). 1781-1796. doi: 10.1016/j.jacc.2018.02.045.
40. Ahmadi N., Ahmadi F., Sadiqi M., Ziemnicka K., Minczykowski A. Thyroid gland dysfunction and its effect on the cardiovascular system: a comprehensive review of the literature. Endokrynol Pol. 2020. 71(5). 466-478. doi: 10.5603/EP.a2020.0052.
41. Chrysant S.G. The current debate over treatment of subclinical hypothyroidism to prevent cardiovascular complications. Int J Clin Pract. 2020 Jul. 74(7). e13499. doi: 10.1111/ijcp.13499.
42. Udovcic M., Pena R.H., Patham B., Tabatabai L., Kansara A.. Hypothyroidism and the Heart. Methodist Debakey Cardiovasc J. 2017 Apr-Jun. 13(2). 55-59. doi: 10.14797/mdcj-13-2-55.
43. Niknam N., Khalili N., Khosravi E., Nourbakhsh M. Endothelial dysfunction in patients with subclinical hypothyroidism and the effects of treatment with levothyroxine. Adv Biomed Res. 2016 Mar 16. 5. 38. doi: 10.4103/2277-9175.178783.
44. Delitala A.P., Fanciulli G., Maioli M., Delitala G. Subclinical hypothyroidism, lipid metabolism and cardiovascular disease. Eur J Intern Med. 2017 Mar.38. 17-24. doi: 10.1016/j.ejim.2016.12.015.
45. Hussain A., Elmahdawi A.M., Elzeraidi N.E., Nouh F., Algathafi K. The Effects of Dyslipidemia in Subclinical Hypothyroidism. Cureus. 2019 Nov 16. 11(11). 6173. doi: 10.7759/cureus.6173.
46. Palmeiro C., Davila M.I., Bhat M., Frishman W.H., Weiss I.A. Subclinical hyperthyroidism and cardiovascular risk: recommendations for treatment. Cardiol Rev. 2013 Nov-Dec. 21(6). 300-8. doi: 10.1097/CRD.0b013e318294f6f1.
47. Marchiori R.C., Pereira L.A., Naujorks A.A., Rovaris D.L., Meinerz D.F., Duarte M.M., Rocha J.B. Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment. BMC Endocr Disord. 2015 Jun 23. 15. 32. doi: 10.1186/s12902-015-0032-3.
48. Dong X., Yao Z., Hu Y., Yang N., Gao X., Xu Y., Wang G. Potential harmful correlation between homocysteine and low-density lipoprotein cholesterol in patients with hypothyroidism. Medicine (Baltimore). 2016 Jul. 95(29). e4291. doi: 10.1097/MD.0000000000004291.
49. Akbaba G., Berker D., Isık S., Tuna M.M., Koparal S., Vural M., Yılmaz F.M., Topcuoglu C., Guler S. Changes in the before and after thyroxine treatment levels of adipose tissue, leptin, and resistin in subclinical hypothyroid patients. Wien Klin Wochenschr. 2016 Aug. 128(15-16). 579- 85. doi: 10.1007/s00508-015-0865-9.
50. Homoncik M., Gessl A., Ferlitsch A., Jilma B., Vierhapper H. Altered platelet plug formation in hyperthyroidism and hypothyroidism. J Clin Endocrinol Metab. 2017. 92. 3006-12.
Review
For citations:
Grin' N.O., Serebryakova O.V., Serkin D.M. MARKERS OF ENDOTHELIAL DYSFUNCTION IN HYPOTHYROIDISM: REVIEW OF LITERATURE. Transbaikalian Medical Bulletin. 2021;(3):70-80. (In Russ.) https://doi.org/10.52485/19986173_2021_3_70
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