CHANGES IN VASCULAR - PLATELET AND PLASMA HEMOSTASIS IN DIALYSIS PATIENTS DURING DIFFERENT PERIODS OF DIALYSIS THERAPY

Abstract

The aim of the research. To study the statement of vascular-platelet link of hemostasis and blood coagulation in dialysis patients during different periods of dialysis therapy.

Materials and methods. Hemostasis analysis was performed in 76 dialysis patients. The number of blood platelets, platelet aggregation, the content and activity of Willebrand factor, as well as screening indicators of plasma hemostasis, indicators of activation of blood clotting, levels of physiological anticoagulants, and indicators of fibrinolysis were determined.

Results. In dialysis patients, multidirectional changes in hemostasis are detected. During the first year of dialysis therapy, there is a slight decrease in platelet aggregation, followed by platelet aggregation increases. An increase in the content of the Willebrand factor is not accompanied by a significant increase in its activity. In dialysis patients, an increase in blood fibrinogen is recorded The increase in soluble fibrinmonomer complexes and D – dimer reflects both the activation of coagulation processes and the response of fibrinolysis. With a duration of dialysis therapy of 13-36 months, the concentration of D-dimer is significantly lower compared to patients on dialysis for less than 1 year and more than 3 years, which suggests a lower risk of hypercoagulation complications in dialysis patients during this period.

Conclusions. For the prognosis and prevention of thrombotic and hemorrhagic complications, individual assessment of coagulation parameters in each patient is necessary.