CLIPPERS-SYNDROME – A NEUROLOGICAL ORPHAN DISORDER
https://doi.org/10.52485/19986173_2026_2_208
Abstract
CLIPPERS syndrome is a rare chronic inflammatory disease of the central nervous system, predominantly affecting the brainstem and cerebellum. Its pathognomonic radiological sign is multiple punctate and linear contrast-enhancing foci in the pons (the "salt-and-pepper" sign), detected on contrast-enhanced magnetic resonance imaging. Diagnosis is challenging due to the condition's rarity and low awareness among physicians. A key feature of the syndrome is its pronounced positive response to corticosteroid therapy. Presented clinical case ample emphasizes the importance of timely recognition of this treatable pathology for initiating effective treatment.
Keywords
Supporting agencies: The study had no financial support. The authors declare that there is no conflict of interest.
About the Authors
Yu. N. Bykov
Irkutsk State Medical University
Russian Federation
Russian Federation
Yury Nikolaevich Bykov, Doctor of Medical Sciences, Professor, Head of the Department of Nervous Diseases
1, Krasnogo Vosstaniya St., Irkutsk, Russia, 664003
E. I. Panferova
Irkutsk State Medical University
Russian Federation
Russian Federation
Elena Igorevna Panferova, clinical resident of the Department of Nervous Diseases
1, Krasnogo Vosstaniya St., Irkutsk, Russia, 664003
Yu. A. Skvortsova
Irkutsk State Medical University
Russian Federation
Russian Federation
Yulia Alekseevna Skvortsova, clinical resident of the Department of Nervous Diseases
1, Krasnogo Vosstaniya St., Irkutsk, Russia, 664003
T. B. Bender
Irkutsk State Medical University
Russian Federation
Russian Federation
Tatiana Borisovna Bender, Candidate of Medical Sciences, Associate Professor of the Department of Nervous Diseases
1, Krasnogo Vosstaniya St., Irkutsk, Russia, 664003
T. N. Zagvozkina
Clinics of the Irkutsk State Medical University
Russian Federation
Russian Federation
Tatiana Nikolaevna Zagvozkina, Head of the Neurological Department of the Clinics
18, Gagarin Blv., Irkutsk, Russia, 664003
I. V. Anikina
Clinics of the Irkutsk State Medical University
Russian Federation
Russian Federation
Irina Viktorovna Anikina, neurologist of the Neurological Department
18, Gagarin Blv., Irkutsk, Russia, 664003
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Review
For citations:
Bykov Yu.N., Panferova E.I., Skvortsova Yu.A., Bender T.B., Zagvozkina T.N., Anikina I.V. CLIPPERS-SYNDROME – A NEUROLOGICAL ORPHAN DISORDER. Transbaikalian Medical Bulletin. 2026;(2):208-217. (In Russ.) https://doi.org/10.52485/19986173_2026_2_208
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