THE PREDICTIVE VALUE OF NEUTROPHIL-TO-LYMPHOCYTE AND PLATELET-TOLYMPHOCYTE RATIOS FOR ASSESSING SEVERITY OF ROTAVIRUS GASTROENTERITIS IN CHILDREN
https://doi.org/10.52485/19986173_2025_4_10
Abstract
The aim of the research. To evaluate the diagnostic and prognostic significance of the neutrophil-tolymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for predicting the severity of rotavirus gastroenteritis (RVGE) in children.
Materials and methods. A prospective study was conducted involving 45 children with RVGE, stratified into groups with mild-to-moderate (n = 16) and severe (n = 29) disease according to the Vesikari scale. NLR and PLR were calculated upon admission. Statistical analysis included the Mann-Whitney U test, ROC analysis, and multivariate logistic regression.
Results. The median NLR and PLR were significantly higher in the severe group compared to the mild-tomoderate group: 4,26 [2,01–5,76] vs 1,64 [0,95–3,71] (p = 0.010) and 165,10 [122,69–244,30] vs 84,79 [67,19–149,93] (p < 0.001), respectively. ROC analysis demonstrated good diagnostic accuracy for predicting severe disease: the area under the curve (AUC) for PLR was 0,794 (95% CI: 0,655–0,945), and for NLR it was 0,750 (95% CI: 0,588–0,912). In the multivariate analysis, only NLR remained an independent predictor of severe course (OR = 3,203; 95% CI: 1,293–7,939; p = 0.012).
Conclusion. NLR and PLR are significant and readily available biomarkers associated with the severity of rotavirus gastroenteritis in children. NLR demonstrated properties of an independent prognostic factor, supporting its use for early risk stratification and therapy optimization.
About the Authors
E. V. Andreeva
Chita State Medical Academy
Russian Federation
Russian Federation
Andreeva E.V., Candidate of Medical Sciences, Associate Professor of the Department of Polyclinic Pediatrics, with acourse in Medical Rehabilitation
39a Gorky St., Chita, 672000
N. A. Miromanova
Chita State Medical Academy
Russian Federation
Russian Federation
Miromanova N.A., Doctor of Medical Sciences, Associate Professor, Head of the Department of Children's Infectious Diseases
39a Gorky St., Chita, 672000
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Review
For citations:
Andreeva E.V., Miromanova N.A. THE PREDICTIVE VALUE OF NEUTROPHIL-TO-LYMPHOCYTE AND PLATELET-TOLYMPHOCYTE RATIOS FOR ASSESSING SEVERITY OF ROTAVIRUS GASTROENTERITIS IN CHILDREN. Transbaikalian Medical Bulletin. 2025;(4):10-18. (In Russ.) https://doi.org/10.52485/19986173_2025_4_10
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