THE ROLE OF SUCCINATE IN METABOLISM REGULATION: PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ASPECTS
https://doi.org/10.52485/19986173_2025_3_85
Abstract
The central link in the cell's energy metabolism are the substrates and enzymes of the Krebs cycle, as well as the electron transport chain of the mitochondria. Metabolites of the Krebs cycle are also present in the bloodstream and perform important functions outside the cycle. The aim of this review is to establish new concepts on the mechanisms of action of succinate in stress situations, taking into account the mechanism of substrate phosphorylation.
To study scientific achievements in the field of energy metabolism, such methods as system-structural and comparative were used. The use of the designated methods allowed us to present the author's scheme, displaying the general patterns of metabolic changes in succinate during hypoxia, inflammation and tumor growth.
Molecular mechanisms of succinate action associated with the development of pathological conditions have been identified. The features of the action of the enzyme succinate dehydrogenase are considered. It has been established that energy-dependent processes dominate in maintaining the main functional systems of the body. Potential molecular markers that reflect real value in monitoring the dynamics of the pathological process have been identified.
A conclusion is formulated about the need for further study of the role of succinate in cellular energy homeostasis for both fundamental science and clinical medicine.
About the Author
E. A. Teplyashina
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Teplyashina E.A., Candidate of Biological Sciences, Associate Professor of the Department of Biological Chemistry with courses in Medical, Pharmaceutical and Toxicological chemistry
1 Partizana Zheleznyaka St., Krasnoyarsk, 660022
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Review
For citations:
Teplyashina E.A. THE ROLE OF SUCCINATE IN METABOLISM REGULATION: PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL ASPECTS. Transbaikalian Medical Bulletin. 2025;(3):85-95. (In Russ.) https://doi.org/10.52485/19986173_2025_3_85
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