ACUTE RESPIRATORY FAILURE DUE TO METHADONE POISONING
https://doi.org/10.52485/19986173_2025_4_173
Abstract
A review of the literature is presented with a clinical example of poisoning with a mixture of psychotropic substances such as methadone and tetrahydrocannabinol, complicated by toxic pulmonary edema.
About the Authors
D. S. Shilin
City Clinical Hospital No 1;
Chita State Medical Academy
Russian Federation
Russian Federation
Shilin D.S., Candidate of Medical Sciences, Anesthesiologist-resuscitator, Assistant of the Department of Anesthesiology, Resuscitation and Intensive Care
8 Lenina St., Chita, 672039;
39a Gorky St., Chita, 672000
D. V. Fedorovtsev
City Clinical Hospital No 1
Russian Federation
Russian Federation
Fedorovtsev D.V., Anesthesiologist-resuscitator of the Resuscitation and Intensive Care Department
8 Lenina St., Chita, 672039
R. M. Kazakov
City Clinical Hospital No 1
Russian Federation
Russian Federation
Kazakov R.M., Anesthesiologist-resuscitator of the Resuscitation and Intensive Care Department, Toxicologist of the Acute Poisoning Department
8 Lenina St., Chita, 672039
K. G. Shapovalov
City Clinical Hospital No 1;
Chita State Medical Academy
Russian Federation
Russian Federation
Shapovalov K.G., Doctor of Medical Sciences, Professor, Anesthesiologist-resuscitator, Head of the Department of Anesthesiology and Resuscitation
8 Lenina St., Chita, 672039;
39a Gorky St., Chita, 672000
References
1. Regina A.C., Goyal A., Mechanic O. J. Opioidtoxicity. Stat Pearls [Internet]. Stat Pearls Publishing, 2025.
2. Welsh C., Doyon S., Hart K. Methadone exposures reported to poison control centers in the United States following the COVID-19-related loosening of federal methadone regulations. International Journal of Drug Policy. 2022. 102. 103591.
3. Rostam-Abadi Y. et al. Public health risks associated with methadone in Iran: A systematic review and meta-analysis. International Journal of Drug Policy. 2022.100. 103529.
4. Fugelstad A. et al. Methadone related deaths among youth and young adults in Sweden 2006–15. Addiction. 2021. 116. 2. 319–327.
5. Livanov G.A., Loladze A.T., Batocyrenov B.V., at all Ostrye otravleniya metadonom (dol'finom) (obzor). Obshchaya reanimatologiya. 2017; 13 (3): 48–63. https://doi.org/10.15360/1813-9779-2017-3-48-63.
6. Udal'cov M.A., Pshenisnov K.V., Aleksandrovich YU. At all Prediktory neblagopriyatnogo techeniya ostryh otravlenij u detej. Obshchaya reanimatologiya. 2025; 21 (2): 25–33. https://doi.org/10.15360/1813-9779-2025-2-2546.
7. Flanagan R.J., Shepherd R.T. Methadone-related death in detention. Journal of forensic and legal medicine. 2022. 88. 102356.
8. Livanov G.A., Lodyagin A.N., Razina A.A., at all Blagopriyatnyj iskhod ostrogo tyazhelogo otravleniya metadonom (klinicheskoe nablyudenie). Obshchaya reanimatologiya. 2018; 14 (5): 25–31. https://doi.org/10.15360/1813-9779-2018-5-25-31.
9. Flanagan R.J., Shepherd R.T. Methadone-related death in detention. Journal of forensic and legal medicine. 2022. 88. 102356.
10. Taheri S.K. et al. One-year survey of methadone-induced Cardiac complications. Caspian Journal of Internal Medicine. 2023. 14. 1. 43.
11. Dorooshi G. et al. Cardiovascular Complications Following Acute Methadone Poisoning in Patients with and Without a History of Long-term Methadone Use Journal of Research in Pharmacy Practice. 2024. 13. 2. 58–64.
12. Eizadi-Mood N. et al. Prevalence of pulmonary edema among the deceased cases with acute Methadone poisoning: A report from Iran. Journal of research in pharmacy practice. 2016. 5. 4. 290–293.
13. Buschmann C. Suicidal wrist bites Forensic Science, Medicine and Pathology. 2024. 1–5.
14. Saari T.I., Strang J., Dale O. Clinical pharmacokinetics and pharmacodynamics of naloxone Clinical pharmacokinetics. 2024. 63. 4. 397–422.
15. Marshall K.D. et al. Revive and refuse: Capacity, autonomy, and refusal of care after opioid overdose The American Journal of Bioethics. 2024. 24. 5. 11–24.
16. Kummer R.L. et al. Naloxone-associated pulmonary edema following recreational opioid overdose The American Journal of Emergency Medicine. 2022. 53. 41–43.
17. Winnicka L., Shenoy M. A. EVALI and the pulmonary toxicity of electronic cigarettes: a review Journal of general internal medicine.2020. 35. 2130–2135.
18. Shilin D.S., Shapovalov K.G. Gemodinamika pri perevode v pron-poziciyu pacientov s COVID-19 Obshchaya reanimatologiya. 2021. 17. 3. S. 32–41.
Review
For citations:
Shilin D.S., Fedorovtsev D.V., Kazakov R.M., Shapovalov K.G. ACUTE RESPIRATORY FAILURE DUE TO METHADONE POISONING. Transbaikalian Medical Bulletin. 2025;(4):173-180. (In Russ.) https://doi.org/10.52485/19986173_2025_4_173
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