ACUTE KIDNEY INJURY IN PATIENTS WITH ACUTE CORONARY SYNDROME WITH ST-SEGMENT ELEVATION AND CONCOMITANT METABOLIC SYNDROME UNDER PHARMACOINVASIVE STRATEGY

The aim of the study was to analyze the frequency and risk factors of acute kidney injury (AKI) in patients with ST-segment elevation acute coronary syndrome (STE-ACS) and concomitant metabolic syndrome (MS) under the pharmacoinvasive treatment strategy.
Material and Methods. The study covered 78 patients divided into two groups: group 1 – STE-ACS patients with concomitant MS (n = 36); group 2 – STE-ACS patients without MS (n = 42).
Results. The study established statistically valid differences between the two groups of STE-ACS patients by a number of indicators. In particular, there were differences in baseline values of the body mass index (BMI) (p = 0,001) and total cholesterol concentration (TC) (р < 0,001), triglycerides (TG) (р = 0,007), triglycerideglucose index (TyG) (р < 0,001), and the creatinine level: on day 1 (р < 0,006), on days 2 and 3 (p < 0,001). On day 2, the glomerular filtration rate (GFR) averaged in group 1 to 66,7 ± 12,2, and in group 2 – to 57,3 ± 8,7 ml/min/1,73m2 (p < 0,001). AKI signs were observed in group 1 in 8 (22,2%) patients, in group 2 – in 2 (4,8%) patients. Along with AKI, the group 1 patients experienced other complications more frequently: cardiac rhythm disorder (р < 0,04) and pulmonary edema (р < 0,034). There were also established valid differences in the treatment duration: the group 1 patients stayed longer in the intensive care unit (ICU) (р = 0,042) and hospital (р = 0,035).
Conclusion. The STE-ACS patients with concomitant MS demonstrated signs of AKI 5,7 times more often than the patients without MS. The study revealed the following factors associated with the AKI development: high BMI (р < 0,001), increased TC in blood (р = 0,01), TG (р = 0,007), TyG (р = 0,036).

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