Anaplastic thyroid cancer: diagnostic challenges
E. V. Kayukova,
N. I. Troitskaya,
Yu. A. Nomokonova,
T. V. Burdinskaya,
S. N. Konyukova,
A. V. Apatova https://doi.org/10.52485/19986173_2025_1_217
Abstract
Anaplastic thyroid cancer is a highly aggressive malignant neoplasm characterized by rapid growth and an extremely unfavorable prognosis. The incidence of this tumor is 1-2% of all thyroid cancer cases. Diagnosis of this type of malignant tumor is often associated with significant difficulties associated with a large morphological diversity of tumor cells. The article presents a clinical case reflecting the difficulties in diagnosing anaplastic thyroid cancer. The role and capabilities of radiation, cytological, pathological, immunohistochemical and molecular genetic research methods for the timely diagnosis of this type of malignant neoplasm are discussed. It is necessary to remember the possibility of detecting anaplastic thyroid cancer in patients with a tumor with signs of malignancy in the organ not only to oncologists, but also to therapists, endocrinologists and surgeons for timely referral and additional examination of patients, given the extremely unfavorable prognosis of the disease.
About the Authors
E. V. Kayukova
Chita State Medical Academy
Russian Federation
Russian Federation
Elena V. Kayukova - Doctor of Medical Sciences, Associate Professor, Head of the Oncology Department.
39a Gorky st., Chita, 672000
N. I. Troitskaya
Chita State Medical Academy
Russian Federation
Russian Federation
Natalia I. Troitskaya - Candidate of Medical Sciences, Associate Professor of the Oncology Department.
39a Gorky st., Chita, 672000
Yu. A. Nomokonova
Transbaikal Regional Oncology Dispensary
Russian Federation
Russian Federation
Yulia A. Nomokonova - Physician of the Head and Neck Tumors Department.
104 Leningradskaya st., Chita, 672027
T. V. Burdinskaya
Transbaikal Regional Oncology Dispensary
Russian Federation
Russian Federation
Tatyana V. Burdinskaya - Head of the Pathological Anatomy Department.
104 Leningradskaya st., Chita, 672027
S. N. Konyukova
Transbaikal Regional Oncology Dispensary
Russian Federation
Russian Federation
Svetlana N. Konyukova– Pathologist.
104 Leningradskaya st., Chita, 672027
A. V. Apatova
Transbaikal Regional Oncology Dispensary
Russian Federation
Russian Federation
Anna V. Apatova– Pathologist.
104 Leningradskaya st., Chita, 672027
References
1. Tarakanova O. V., Slavnova E. N., Korobkova, T. A., et al. Anaplastic thyroid carcinoma. Possibilities of morphological diagnostics. Clinical case. Novosti klinicheskoj citologii Rossii. 2022. 26(4). 14-18. DOI: 10.17116/patol20208206155. In Russian.
2. Xu L., Cai L., Zhu Z., et al. Comparison of the cox regression to machine learning in predicting the survival of anaplastic thyroid carcinoma. BMC Endocr Disord. 2023. 23. 129. doi: 10.1186/s12902-023-01368-5.
3. Marchand-Crety C., Pascard M., Debreuve-Theresette A. et al. Prognostic factors and survival score for patients with anaplastic thyroid carcinoma: a retrospective study from a regional registry. Anticancer Research. 2021. 41(3). 1555-1561. DOI: 10.21873/anticanres.14915.
4. Mudunov A. M., Pheshhova B. G., Zejnalova P. A. et al.. Difficulties in diagnostics and clinical features of anaplastic thyroid cancer. Clinical case. Klinicheskij sluchaj. MD-onco. 2022. 2(4). 22-26. doi. org/10.17650/2782-3202-2022-2-4-22-26. In Russian.
5. Luk'janov S. A., Sergijko S. V., Titov S. E. et al.. New Possibilities of Preoperative Diagnostics of Anaplastic Thyroid Cancer. Opuholi golovy i shei. 2021. 11(1). 34-40. doi.org/10.17650/2222-1468-2021-11-1-34-40. In Russian.
6. Cleere E. F., Prunty S., O'Neill J. P. Anaplastic thyroid cancer: Improved understanding of what remains a deadly disease. The Surgeon. 2024. 22(1). e48-e53. DOI: 10.1016/j.surge.2023.10.002.
7. Pylev A. L., Zhandarova A. A., Petrov K. S. et al. Anaplastic Thyroid Cancer: Is There Light at the End of the Tunnel? Opuholi golovy i shei. 2020. 10(1). 10-19. doi.org/10.17650/2222-1468-2020-10-1-10-19. In Russian.
8. Jannin A., Escande A., Al Ghuzlan A. et al. Anaplastic thyroid carcinoma: an update. Cancers. 2022. 14(4), 1061. DOI: 10.3390/cancers14041061.
9. Bel'cevich D.G., Mudunov A.M., Vanushko Je.M. et al. Differentiated thyroid cancer. Clinical guidelines. Klinicheskie rekomendacii. 2020. 56. doi.org/10.17650/2222-1468-2020-10-1-10-19. In Russian.
10. Shi M., Nong D., Xin M., et al. Accuracy of Ultrasound Diagnosis of Benign and Malignant Thyroid Nodules: A Systematic Review and Meta‐Analysis. International Journal of Clinical Practice. 2022. 2022(1). 5056082. DOI: 10.1155/2022/5056082.
11. Shao C., Li Z., Zhang C. et al. Optical diagnostic imaging and therapy for thyroid cancer. Materials Today Bio. 2022. 17. 100441. DOI: 10.1016/j.mtbio.2022.100441
12. Pavlidis E. T., Galanis I. N., Pavlidis T. E. Update on current diagnosis and management of anaplastic thyroid carcinoma. World Journal of Clinical Oncology. 2023. 14(12). 570. DOI: 10.5306/wjco.v14.i12.570.
13. Marchand-Crety C., Pascard M., Debreuve-Theresette A. et al. Prognostic factors and survival score for patients with anaplastic thyroid carcinoma: a retrospective study from a regional registry. Anticancer Research. 2021. 41(3). 1555-1561. DOI: 10.21873/anticanres.14915.
14. Podany P., Abi-Raad R., Barbieri A. et al. Anaplastic thyroid carcinoma: Cytomorphologic features on fine-needle aspiration and associated diagnostic challenges. American Journal of Clinical Pathology. 2022. 157(4). 608-619. DOI: 10.1093/ajcp/aqab159.
15. Lind P., Jacobson A., Nordenström E. et al. Diagnostic sensitivity of fine-needle aspiration cytology in thyroid cancer. Scientific Reports. 2024. 14(1). 24216. DOI: 10.1038/s41598-024-75677-7.
16. Kostromina E.V., Krasil'nikova L.A., Deniskin O.N. et al. Multidisciplinary approach to diagnostics of focal changes in the thyroid gland during primary diagnostics: a teaching aid for students in the system of higher and additional professional education. Sankt-Peterburg: NMIC onkologii im. N.N. Petrova, 2022. 158. ISBN 978-5-6046979-4-8. In Russian.
17. Jannin A., Escande A., Al Ghuzlan A. et al. Anaplastic thyroid carcinoma: an update. Cancers. 2022. 14(4). 1061. DOI: 10.3390/cancers14041061.
18. Musonova A. K., Nazarov V. D., Sidorenko D. V. et al. Molecular genetic features of anaplastic thyroid carcinoma. Rossijskij onkologicheskij zhurnal. 2022. 27(2). 59-70. DOI:10.17816/onco115251.
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For citations:
Kayukova E.V., Troitskaya N.I., Nomokonova Yu.A., Burdinskaya T.V., Konyukova S.N., Apatova A.V. Anaplastic thyroid cancer: diagnostic challenges. Transbaikalian Medical Bulletin. 2025;(1):217-228. (In Russ.) https://doi.org/10.52485/19986173_2025_1_217
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