Frequency of alleles and genotypes of the SCNN1G gene variant (rs4401050) in patients with arterial hypertension
https://doi.org/10.52485/19986173_2023_4_27
Abstract
The aim of the research. Was to study of the frequency of variant alleles and genotypes of SNV gene SCNN1G (rs4401050) of the epithelial sodium channel in patients with arterial hypertension and in healthy people in the Trans-Baikal region.
Materials and methods. The research included patients with arterial hypertension (135 people) using a continuous sampling method. The control group consisted of 106 practically healthy donors. Determination of SNV of the SCNN1G gene (rs4401050) was carried out using the real polymerase chain reaction method.
Results. The study of the distribution of SNVs of the SCNN1G gene (rs4401050) in a group of patients with arterial hypertension and in the control group was established that carriage of the C/C genotype in the group of patients with hypertension was more common than in the control group (62% and 38,7%, respectively; χ2 = 7,49, p = 0,006). This way carriage of the C/C genotype of the SCNN1G gene increased the likelihood of hypertension in patients (OR = 2,70, 95% CI 1,60 – 4,55, p = 0,0002). Among patients, allele C was detected 1,2 times more often, with a frequency of 0,79 compared to a group of healthy individuals – 0.68 (χ2 = 7,49, p = 0,006). It was found that the T allele of the SCNN1G gene (rs4401050) in patients with hypertension was 1,5 times less common than in the control group, and its frequency was 0,22 versus 0,33, respectively (χ2 = 7,49, p = 0,006). Carriage of the T allele (genotypes T/T+ C/T) is associated with a lower incidence in patients with hypertension (OR = 0,33, 95% CI 0,20–0.57, p = 0,0002). On the samples we examined, carriage of the T allele reduced the likelihood of hypertension by 1,5 times.
Conclusion. In the studied sample, the carrying of the allele C of the gene SCNN1G (rs4401050) in homozygous form supposedly increases the probability of AG development.
About the Authors
Z. A. Pokoeva
Chita State Medical Academy
Russian Federation
Russian Federation
39 a, Gorky street, Chita, 672000
B. S. Pushkarev
Chita State Medical Academy
Russian Federation
Russian Federation
39 a, Gorky street, Chita, 672000
O. V. Bolshakova
Chita State Medical Academy
Russian Federation
Russian Federation
39 a, Gorky street, Chita, 672000
Yu. A. Vitkovskiy
Chita State Medical Academy
Russian Federation
Russian Federation
39 a, Gorky street, Chita, 672000
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Review
For citations:
Pokoeva Z.A., Pushkarev B.S., Bolshakova O.V., Vitkovskiy Yu.A. Frequency of alleles and genotypes of the SCNN1G gene variant (rs4401050) in patients with arterial hypertension. Transbaikalian Medical Bulletin. 2023;(4):27-33. (In Russ.) https://doi.org/10.52485/19986173_2023_4_27
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