Immunogenetic and molecular mechanisms of varicella pathogenesis
https://doi.org/10.52485/19986173_2023_3_80
Abstract
The literature review presents an analysis of publications by Russian and foreign authors on clinical and laboratory indicators characterizing the immune system of patients with varicella, using modern databases – RSCI, PubMed, Scopus. Taking into account the urgency of the problem of infectious disease, insufficient knowledge and the presence of contradictory results of scientific researchers in the field of immunopathogenesis of varicella, the expediency of further study of the designated direction in science has been revealed.
About the Authors
T. A. Krivoluckaya
Branch No.2 of the 1477 Naval Clinical Hospital; Chita State Medical Academy
Russian Federation
Russian Federation
1 Ammonal Pad Street, Petropavlovsk-Kamchatsky, 683015
39а Gorky Street, Chita, 672000
A. N. Emelyanova
Chita State Medical Academy
Russian Federation
Russian Federation
39а Gorky Street, Chita, 672000
A. B. Makarov
Military Medical Academy named after S.M. Kirov
Russian Federation
Russian Federation
6 Akademika Lebedeva Street, St. Petersburg, 194044
A. S. Emelyanov
Chita State Medical Academy
Russian Federation
Russian Federation
39а Gorky Street, Chita, 672000
References
1. Skripchenko N.V., Fridman I.V., Ivanova G.P., Vilnits A.A., Pulman N.F., Gorelik E.Yu., Astapova A.V. Chicken-pox nowadays: «silent» epidimics and possibilities of specific prophilaxys. Polyclinic. 2022. 1. 47-53. in Russian.
2. Prikhodchenko NG. Varicella-pox virus infection: features of the course, clinical manifestations, complications, and possibilities for prevention. Terapevticheskii Arkhiv. 2021. 93(11). 1401–1406. DOI 10.26442/00403660.2021.11.201192. in Russian.
3. Varicella and herpes zoster vaccines: WHO position paper. 2014. Weekly Epidemiological Record. 2014. 89(25). 265-287. DOI 10.1016/j.vaccine.2014.07.068.
4. Aschner C.B., Herold B.C. Alphaherpesvirus Vaccines. Current Issues in Molecular Biology. 2021. 41. 469-508. DOI 10/21775/cimb.041.469.
5. Oliver S.L., Zhou M., Arvin A.M. Varicella-zoster virus: molecular controls of cell fusion-dependent pathogenesis. Biochemical Society Transactions. 2020. 48(6). 2415-2435. DOI 10.1042/BST20190511.
6. Skripchenko E. Yu, Ivanova G. P., Skripchenko N.V., Vilnitz A.A., Pulman N.F., Gorelik E. Yu., Astapova A.V., Fridman I.V. Modern view on the features of varicella in children and the possibility of specific prevention. Practical medicine. 2021. 19(2). 8-13. DOI 10.32000/2072-1757-2021-2-8-13. in Russian.
7. Wakim L.M., Woodward A., Bevan M.J. Mamory T-cell persisting within the brain after local infection show functional to their tissue of residence. Proceedings of the National Academy of Sciences. 2010. 107. 17872 - 17879. DOI 10.1073/pnas.1010201107.
8. Kashyap S., Shanker V. Zoster ophthalmicus with dissemination in a six year old immunocompetent child. Indian Journal of Dermatology, Venereology and Leprology. 2014. 80. 382. DOI 10.4103/0378-6323.136997.
9. Nagoyev B.S., Kambabatchokova Z.A. The intensity of processes of li-poperoxidant defence in patients viral herpes infection. Klinichescheskaa laboratornaya diagnostika. 2012. 3.19-21. in Russian.
10. Kawai K., Gebremeskel B.G., Acosta C.J. Systematic review of incidence and complications of herpes zoster: towards a global perspective. Bmj: british medical journal: international edition. 2014. 4(6). DOI 10.1136/bmjopen-2014-004833.
11. Lavrov V.F., Svitich O. A., Kazanova A.S., Kinkulkina A.R., Zverev V.V. Varicella zoster virus infection: immunity, diagnosis and modelling in vivo. Microbiology. 2019. 4. 82–89. DOI 10.36233/0372-9311-2019-4-82-89. in Russian.
12. Haberthur K., Engelmann F., Park B., Barron A., Legasse A., Dewane J., Fischer M., Kerns A., Brown M., Messaoudi I. CD4 T cell immunity is critical for the control of simian varicella virus infection in a nonhuman primate model of VZV infection. Plos Pathogens. 2011. 7(11). DOI 10.1371/journal.ppat.1002367.
13. Gabutti G., Franchi M., Maniscalco L., Stefanati A. Varicella-zoster virus: pathogenesis, incidence patterns and vaccination programs. Minerva Pediatr. 2016. 68(3). 213-25. DOI 10.2147/itt.s176383.
14. Tichonova Yu.S., Bulygin G.V., Kuzmina T.Yu., Tichonova E.P. Metabolic processes in limfocytes of pathients with varicella zoster infections. Journal Infectology. 2012. 4(3). 42-45. DOI 10.22625/2072-6732-2012-4-3-42-45. in Russian.
15. Singh P., Karmacharya S., Rizyal A., Rijal A.P. HZO with retrobulbar neuritis. Nepalese Journal Ophthalmology. 2016. 8(15). 78-81. DOI 10.3126/nepjoph.v8i1.16142.
16. Okunuki Y., Sakai J., Kezuka T., Goto H. A case of herpes zoster uveitis with severe hyphemia. BMC Ophthalmology. 2014. 14. 74. DOI 10.1186/1471-2415-14-74.
17. Winsauer C., Kruglov A.A., Chashchina A.A., Drutskaya M.S., Nedospasov S.A. Cellular sources of pathogenic and protective TNF and experimental strategies based on utilization of TNF humanized mice. Cytokine and Growth Factor Reviews. 2014. 25(2). 115–123. DOI 10.1016/j.cytogfr.2013.12.005.
18. Levina A.S., Babachenc I.V. Persistent Infection in Frequent and Prolonged ill Children,Possibilities of Etiopathogenetic TherapyDetskie Infektsii. 2014. 13(4). 41–45. in Russian.
19. Yakubenko A.L., Yakovlev A.A., Musatov V.B., Kingo Z.N., Gorbova I.V., Andreeva I.L., Komarova A.Y. The dynamics of interleukin-6level in HIV-infected patients with herpes zoster. Journal Infectology. 2015;7(2):83-91. DOI 10.22625/2072-6732-2015-7-2-83-91. in Russian.
20. Grinde B. Herpesviruses: latency and reactivation — viral strategies and host response. The Journal of Microbiology. 2013. 5. 227-266. DOI 10.3402/jom.v5i0.22766.
21. Chen J.J., Gershon A.A., Li Z., Cowles A.C., Gershon V.D. Varicella zoster virus (VZV) infects and establishes latency in enteric neurons. Journal of neurobiology. 2011. 17(6). 578-589. DOI 10.1007/s13365-011-0070-1.
22. Gershon A.A., Chen J., Gershon M.D. Use of saliva to identify varicellazoster virus (VZV) infection of the gut. Clinical Infectious Diseases. 2015. 61. 536-44. DOI 10.1093/cid/civ320.
23. Svitich O.A., Gankovskaya L.V., Lavrov V.F. Herpes simplex virus type 2 infection during pregnancy is correlated with elevated TLR9 and TNFα expression in cervical cells. International Trends in Immunity. 2014. 2(1). 62-66.
24. Weller T.H. Intradermal vaccination against influenza. The New England Journal of Medicine. 2005. 352(10). 1044-1046.
25. Zheleznikova G. F., Skripchenko N.V., Skripchenko E. Y. Varicella-zoster and immune response. Russian journal of immunology. 2013. 7. 1(16), 35–48. in Russian.
26. Yu H., Chen R., Hong K., Bong C., Lee W., Kuo H., Yang K.D. IL-12-independent Th1 polarization in human mononuclear cells infected with varicella-zoster virus. European Journal Immunology. 2005. 35. 12. 3664–3672. DOI 10.1002/eji.200526258.
27. Nielsen O.H., Ainsworth M.A. Tumor necrosis factor inhibitors for inflammatory bowel disease. The New England Journal of Medicine. 2013. 369(8). 754–762. DOI 10.1056/NEJMct1209614.
28. Zheleznikova G.F., Skripchenko N.V. Immunopathogenesis of infectious-inflammatory diseases of central nervous system. Journal Infectology. 2011; 3(2): 28-32. DOI 10.22625/2072-6732-2011-3-2-28-32. in Russian.
29. Lafon M., Megret F., Lafage M., Prehaud C. The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA. Journal of Molecular Neuroscience. 2006. 29(3). 185–194. DOI 10.1385/JMN:29:3:185.
30. Yang M., Min K., Joe E. Multiple mechanisms that prevent excessive brain inflammation. Journal of Neuroscience Research. 2007. 85(11). 2298–2305. DOI 10.1002/jnr.21254.
31. Skripchenko E.Yu. Neurological complications and prognosis of their development in children with chickenpox [dissertation ... Candidate of Medical Sciences]. St. Petersburg: SBOU VPO "Senkt-Peterburg State Pediatric Medical Academy" of the Ministry of Health of the Russian Federation. 2013. in Russian.
32. Zheleznikova G.F., Lobzin Y.V., Skripchenko N.V., Ivanova G.P., Skripchenko E.Y., Monakhova N.E. Clinical significance of cytokines serum levels in children with chicken pox. Russian Journal of Infection and Immunity = Infektsiya i immunitet, 2015. 5 (1), 79–84. DOI 10.15789/2220-7619-2015-1-79-84. in Russian.
33. Malavige G.N., Jones L., Kamaladasa S., Wijewickrama A., Seneviratne S., Black A., Ogg G. Viralload, clinical disease severity and cellular immune responses in primary varicella zoster virus infection in Sri Lanka. PLOS One. 2008. 3(11), 3789. DOI 10.1371/journal.pone.0003789.
34. Skripchenko N.V., Ivanova G.P., Komantsev V.N., Savina M.V. Modern features of varicella encephalitis in children. Zhurnal infektologii = Journal of Infectology, 2009, vol. 1, no. 4, pp. 36–43. DOI 10.22625/2072-6732-2009-1-4-36-43. in Russian.
35. Desloges N., Schubert C., Wolff M., Rahaus M. Varicella-zoster virus infection induces the secretion of interleukin-8. Medical Microbiology Immunology. 2008. 197 (3). 277–284. DOI 10.1007/s00430-007-0060-3.
36. Ohfu M., Mazutaki M., Inoue S., Inoue T., Yasumoto S., Ogawa A., Tomoda Y., Tsuru N., Mitsudome A. Interleukin-6 in the cerebrospinal fluid of two patients with herpes zoster meningitis. No to hattatsu, 2001. 33(3). 270–275.
37. Zheleznikova G.F. In infection and immunity: strategies from both sides. Medical Immunology. 2006. 8(5-6). 597-614. DOI 10.15789/1563-0625-2006-5-6-597-614. in Russian.
38. Kawai K., Gebremeskel B.G., Acosta C.J. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open. 2014. 4(6). 1-18. DOI 10.1136/bmjopen-2014-004833.
39. Novakova L. Low numbers and altered phenotype of invariant natural killer T cells in recurrent varicella-zoster virus infection. L. Novakova, A. Lehuen, J. Novak . Celular Immunology. 2011. 269 (2). 78–81. DOI 10.1016/j.cellimm.2011.04.008. in Russian.
40. Banovic T. et al. Disseminated varicella infection caused by varicella vaccine strain in a child with low invariant natural killer T cells and diminished CD1d expression. The Journal of Infectious Diseases. 2011. 204 (12). 1893–1901. DOI 10.1093/infdis/jir660.
Review
For citations:
Krivoluckaya T.A., Emelyanova A.N., Makarov A.B., Emelyanov A.S. Immunogenetic and molecular mechanisms of varicella pathogenesis. Transbaikalian Medical Bulletin. 2023;(3):80-88. (In Russ.) https://doi.org/10.52485/19986173_2023_3_80
Views:
98
Email this article 