The state of the glutathione system in patients with diffuse liver lesions in combination with chronic herpetic infection on the background of a secondary immunodeficiency condition

Aim: to study the state of the glutathione system in patients with diffuse liver lesions in combination with chronic herpes infection on the background of a secondary immunodeficiency condition.
Methods. 47 patients with diffuse liver lesions (DLL), combined with chronic herpetic infection (GI) on the background of secondary immunodeficiency (VIDS) were examined. The study excluded patients with the presence of markers of hepatitis C virus (HCV) and HBV in the blood, after examination by enzyme immunoassay (ELISA), as well as patients with alcoholic and autoimmune hepatitis. All patients were prescribed a biochemical blood test. Using the PEF-3 device, the activity of lactate dehydrogenase (LD) and its isoenzyme spectrum was also determined by electrophoresis in agar gel. In all examined patients, the content of reduced glutathione was additionally investigated, based on the fact that glutathione reacts with an excess of aloxane.
Results. The data obtained indicate a significant decrease in the activity of enzymes of the glutathione system in patients with diffuse liver lesions, combined with chronic herpetic infection against the background of VIDS, which consequently becomes unable to fully resist the damaging effect of excessive lipoperoxidation products accumulating in the blood of patients. There was a certain positive dynamics of the studied biochemical parameters after the completion of treatment of the combined pathology of the hepatobiliary system (GBS) and CGI by conventional methods, but there was no complete restoration of the glutathione system to normal.
Conclusions. When using conventional therapy for the treatment of patients with diffuse liver lesions, combined with chronic herpetic infection against the background of VIDS, positive dynamics is observed on the part of biochemical parameters, but the state of the glutathione system is not fully restored and does not reach the norm.

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