SYNDROME OF DYSPEPSIA IN CHILDREN OF THE TRANSBAIKAL TERRITORY
https://doi.org/10.52485/19986173_2022_3_1
Abstract
Objective. To study the causes and prevalence of symptoms of the syndrome of dyspepsia (SD) in children.
Materials and Methods. The study involved 550 children of the Transbaikal Territory aged 8-15 years with SD. The study was conducted in 2 stages. First, all patients with SD were examined. Then, patients with functional dyspepsia (FD) had a complete examination. Diagnostics of FD was based on the Rome IV criteria. Upper gastrointestinal endoscopy was made in 156 children. Helicobacter pylori (HP) IgM antibodies were detected by ELISA test in the serum.
Results. The organic causes of SD were found in 144 patients (26.2% cases). FD was found in 406 (73.8%) cases. SD occurred more often in girls than in boys. SD was more widespread in the age group of 12-15. There were no ethnic differences in the prevalence of HP infection. The patients with longer duration of symptoms had HP infection more often. HP infection more often occurred in patients with early bottle feeding and family gastritis or ulcer history. One of the possible causes was HP infection. Patients with family history of gastritis or ulcer had HP infection in 72.9% cases.
Conclusion. In the Transbaikal Territory functional causes of SD were more widespread than organic ones.
Probable causes of the FD were considered to be allergy, early bottle feeding and family gastritis / ulcer history. Antibodies to HP were found in 57% patients. The most widespread symptom in patients, infected with HP, was bothersome epigastric burning.
About the Author
V. A. Shcherbak
Chita State Medical Academy
Russian Federation
Russian Federation
39a Gorky Street, Chita, 672000
References
1. Baaleman D.F., Velasco-Benítez C.A., Méndez-Guzmán L.M., Benninga M.A., Saps M. Functional gastrointestinal disorders in children: agreement between Rome III and Rome IV diagnoses. Eur J. Pediatr. 2021. 180(7). 2297-2303. doi: 10.1007/s00431-021-04013-2.
2. Drossman D.A. Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features and Rome IV. Gastroenterology. 2016. 150. 1262-1279 doi: 10.1053/j.gastro.2016.02.032.
3. Schmulson M.J., Drossman D.A. What Is New in Rome IV. J. Neurogastroenterol Motil. 2017. 23(2). 151–163. doi: 10.5056/jnm16214.
4. Malfertheiner P., Megraud F., O'Morain C.A., Gisbert J.P., Kuipers E.J., Axon A.T., Bazzoli F., Gasbarrini A., Atherton J., Graham D.Y., Hunt R., Moayyedi P., Rokkas T., Rugge M., Selgrad M., Suerbaum S., Sugano K., El-Omar E.M. Management of Helicobacter pylori infection-the Maastricht V/Florence Consensus Report. Gut. 2017. 66(1). 6-30. doi: 10.1136/gutjnl-2016-312288.
5. Sugano K., Tack J., Kuipers E.J., Graham D.Y., El-Omar E.M., Miura S., Haruma K., Asaka M., Uemura N., Malfertheiner P. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015. 64. 1353-1367. doi: 10.1136/gutjnl-2015-309252.
6. Du L.J., Chen B.R., Kim J.J., Kim S., Shen J.H., Dai N. Helicobacter pylori eradication therapy for functional dyspepsia: Systematic review and meta-analysis. World J. Gastroenterol. 2016. 22(12). 3486-95. doi: 10.3748/wjg.v22.i12.3486.
7. Sýkora J., Huml M., Siala K., Pomahačová R., Jehlička P., Liška J., Kuntscherová J., Schwarz J. Paediatric Rome III Criteria-Related Abdominal Pain Is Associated With Helicobacter pylori and Not With Calprotectin. J. Pediatr Gastroenterol Nutr. 2016. 63(4). 417-22. doi: 10.1097/MPG.0000000000001172.
8. Ford A.C., Tsipotis E., Yuan Y., Leontiadis G.I., Moayyedi P. Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis. Gut. 2022. 12:gutjnl-2021-326583. doi: 10.1136/gutjnl-2021-326583
9. Stanghellini V., Chan F.K.L, Hasler W.L., Malagelada J.R., Suzuki H., Tack J., Talley N.J. Gastroduodenal Disorders. Gastroenterology. 2016. 150. 1380–1392. doi.org/10.1053/j.gastro.2016.02.011
10. Hyams J.S., Di Lorenzo C., Saps M., Shulman R.J., Staiano A., van Tilburg M. Functional disorders: children and adolescents. Gastroenterology. 2016. 150. 1456–1468.e2. doi: 10.1053/j.gastro.2016.02.015.
11. Rajindrajith S., Zeevenhooven J., Devanarayana N.M., Perera B.J.C., Benninga M.A. Functional abdominal pain disorders in children. Expert Rev Gastroenterol Hepatol. 2018. 12(4). 369-390. doi: 10.1080/17474124.2018.1438188.
12. Korterink J., Devanarayana N.M., Rajindrajith S., Vlieger A., Benninga M.A. Childhood functional abdominal pain: mechanisms and management. Nat Rev Gastroenterol Hepatol. 2015. 12(3). 59-71. doi: 10.1038/nrgastro.2015.21.
13. Miller J., Khlevner J., Rodriguez L. Upper Gastrointestinal Functional and Motility Disorders in Children. Pediatr Clin North Am. 2021. 68(6). 1237-1253. doi: 10.1016/j.pcl.2021.07.009
14. Polivanova T.V., Vshivkov V.A. Helicobacter Pylori and familial factors. Journal of Gastroenterology and Hepatology. 2021. 36(S2). 186-187.
15. Vshivkov V.A., Polivanova T.V. The prevalence of CaGA Helicobacter Pylori in children of the Mongoloid population of Siberia. Helicobacter. Supplement. 2020. 25(S1). EP5.05. DOI: 10.1111/hel.12745.
16. Wauters L., Nightingale S., Talley N.J., Sulaiman B., Walker M.M. Functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohort. Aliment Pharmacol Ther. 2017. 45(10). 1358-1364. doi: 10.1111/apt.14045.
17. Chumpitazi B.P. Update on Dietary Management of Childhood Functional Abdominal Pain Disorders. Gastroenterol Clin North Am. 2018. 47(4). 715-726. doi: 10.1016/j.gtc.2018.07.001.
18. Jones N.L., Koletzko S., Goodman K., Bontems P., Cadranel S., Casswall T., Czinn S., Gold B.D., Guarner J., Elitsur Y., Homan M., Kalach N., Kori M., Madrazo A., Megraud F., Papadopoulou A., Rowland M. Joint ESPGHAN/NASPGHAN Guidelines for the Management of Helicobacter pylori in Children and Adolescents (Update 2016). J. Pediatr Gastroenterol Nutr. 2017. 64(6). 991-1003. DOI: 10.1097/MPG.0000000000001594
Review
For citations:
Shcherbak V.A. SYNDROME OF DYSPEPSIA IN CHILDREN OF THE TRANSBAIKAL TERRITORY. Transbaikalian Medical Bulletin. 2022;(3):1-8. https://doi.org/10.52485/19986173_2022_3_1
Views:
74
Email this article 