INFLUENCE OF THE NEW COMPOUND VMA-10-18 ON THE ENDURANCE OF MICE IN THE TREDBAN TEST WITH SUBSEQUENT ASSESSMENT OF SOME BIOCHEMICAL INDICATORS
https://doi.org/10.52485/19986173_2022_2_34
Abstract
The aim of the research. Evaluate the impact of the new connection VMA-10-18 on performance mice in the test «Running on a treadmill» with subsequent evaluation of some biochemical parameters of animals.
Materials and methods. Physical activity was reproduced on the model of the test «Running on a treadmill» with subsequent blood sampling and assessment of biochemical parameters. The test compound and reference drug were administered per os at the respective doses of 10 mg/kg and 25 mg/kg 1 hour before exercise for 10 days. Preliminary assessment of lactate ion and glucose was carried out before the animals started running (day 1) and after the end of the ten-day experiment.
Results and discussions. During the study, it was found that the use of the test compound at a dose of 10 mg/kg increased the endurance of the animals in the experiment, as evidenced by the increase in the duration of the running of mice. The peak physical activity of the group receiving the studied compound was 2.6 times higher (p < 0.05) relative to the day of maximum endurance of the negative control group. It should be noted that lactate, as well as the level of glucose after exercise in this group, was lower by 3.3 (p < 0.05) and 1.8 times (p < 0.05), compared with the negative group. control.
Conclusion. VMA-10-18 improves the performance and endurance of animals against the background of debilitating loads, while correcting the resulting metabolic disorders.
About the Authors
A. D. Gerashchenko
Pyatigorsk medical and pharmaceutical Institute is a branch of the Volgograd state medical University
Russian Federation
Russian Federation
11 Kalinina Ave., Pyatigorsk, Stavropol region, Russia, 357532
N. B. Shabanova
Pyatigorsk medical and pharmaceutical Institute is a branch of the Volgograd state medical University
Russian Federation
Russian Federation
11 Kalinina Ave., Pyatigorsk, Stavropol region, Russia, 357532
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Review
For citations:
Gerashchenko A.D., Shabanova N.B. INFLUENCE OF THE NEW COMPOUND VMA-10-18 ON THE ENDURANCE OF MICE IN THE TREDBAN TEST WITH SUBSEQUENT ASSESSMENT OF SOME BIOCHEMICAL INDICATORS. Transbaikalian Medical Bulletin. 2022;(2):34-40. (In Russ.) https://doi.org/10.52485/19986173_2022_2_34
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