MICROFLOW PARAMETERS IN PATIENTS WITH PNEUMONIA WITH A/H1N1 INFLUENZA WITH ORGAN DYSFUNCTION
https://doi.org/10.52485/19986173_2022_2_1
Abstract
Aims. To assess microcirculation in patients with severe pneumonia with A(H1N1) influenza.
Materials and methods. The study included 30 patients with severe pneumonia with A(H1N1) influenza. The CURB/CRB-65 scales were used to diagnose and assess the severity of pneumonia; SMART-COP, as well as the Federal Clinical Guidelines of the Ministry of Health of the Russian Federation "Community-Acquired Pneumonia in Adults" and the IDSA/ATS criteria. The SOFA scale was used to assess the degree of organ dysfunction. Patients were divided into 2 groups: group 1 (n=20), without signs of organ dysfunction (≤ 2 points on the SOFA scale), group 2 (n=10), with signs of organ dysfunction (≥ 2 points on the SOFA scale). The control group consisted of 15 healthy volunteers. The parameters of microcirculation were assessed by the method of laser Doppler flowmetry (LDF), on the device LAKK-02 (NPP Lazma, Russia).
Results. It was found that in patients with severe pneumonia with signs of organ dysfunction, the microcirculation index decreased, neurogenic and myogenic tone increased, the bypass index increased, both relative to the control group and relative to patients with severe pneumonia without signs of organ dysfunction.
Conclusion. A decrease in the microcirculation index and an increase in the bypass index, on the one hand, reflect the degree of microcirculatory disorders, while, on the other hand, these changes, being pathophysiological components of microhemodynamic insufficiency, contribute to the development of organ dysfunction in patients with severe pneumonia with A(H1N1) influenza.
About the Authors
A. V. Malyarchikov
Chita State Medical Academy
Russian Federation
Russian Federation
39A Gorky str., Chita, 672000
K. G. Shapovalov
Chita State Medical Academy
Russian Federation
Russian Federation
39A Gorky str., Chita, 672000
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Review
For citations:
Malyarchikov A.V., Shapovalov K.G. MICROFLOW PARAMETERS IN PATIENTS WITH PNEUMONIA WITH A/H1N1 INFLUENZA WITH ORGAN DYSFUNCTION. Transbaikalian Medical Bulletin. 2022;(2):1-7. (In Russ.) https://doi.org/10.52485/19986173_2022_2_1
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