LYMPHOTOXIN ALPHA: BIOLOGICAL AND CLINICAL SIGNIFICANCE
https://doi.org/10.52485/19986173_2022_1_44
Abstract
Lymphotoxin α is a one of the tumor necrosis factor family ligand. For almost forty years its pathophysiologic importance as proliferative and inflammatory cytokine was validated. Correlation between some single nucleotide polymorphism and nosological entity was clarified with lyphotoxin’s gene investigation. In clinic it uses in the treatment protocols of rheumatic diseases especially rheumatoid arthritis. Its role in the oncopathological processes is being studied. Lymphotoxin’s system influenced medicines are being researched. Moreover the studying of genomic structure and biochemical aspects under normal and pathological conditions is in process. There are many points of lymphotoxin’s influence on various metabolic ways. The main research results of this cytokine, its genetic structure and its receptors role in pathological conditions and therapeutic approaches, influencing on its system, were observed in the article.
About the Authors
N. E. Garashchenko
Irkutsk state medical university
Russian Federation
Russian Federation
664003, Irkutsk, 1 Krassnogo vosstanija St.
I. Zh. Seminskiy
Irkutsk state medical university
Russian Federation
Russian Federation
664003, Irkutsk, 1 Krassnogo vosstanija St.
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Review
For citations:
Garashchenko N.E., Seminskiy I.Zh. LYMPHOTOXIN ALPHA: BIOLOGICAL AND CLINICAL SIGNIFICANCE. Transbaikalian Medical Bulletin. 2022;(1):44-55. (In Russ.) https://doi.org/10.52485/19986173_2022_1_44
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