NOS3 GENE POLYMORPHISM (G894T) IN PATIENTS WITH A COMBINATION OF BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS
https://doi.org/10.52485/19986173_2024_1_75
Abstract
The aim of the research. We aimed to study the prevalence of genetic variants in the NOS3 gene (G894T) related to nitric oxide production in individuals with both asthma and type 2 diabetes.
Materials and methods. The study was carried out among 240 patients suffering from asthma and diabetes type 2, dividing them into three groups for comparative analysis, each of which had 80 people. Clinical examination and molecular genetic analysis of the polymorphism of nitric oxide synthase NOS3 (G894T) was performed by PCR in all groups.
Results. Patients suffering from type 2 diabetes and asthma have a high frequency of G-allele polymorphism NOS3 894G/T compared with those who have only type 2 diabetes or asthma. The G-allele of the NOS3 894G/T polymorphism contributes to an increased risk of developing diabetes type 2 in patients with asthma.
Conclusion. The study of NOS3 polymorphism (G894T) may be useful to identify a group of patients with asthma who are at increased risk of diabetes type 2.
About the Authors
А. V. Pashkevich
Chita State Medical Academy
Russian Federation
Russian Federation
39а Gorky Street, Chita, 672000
О. V. Serebryakova
Chita State Medical Academy
Russian Federation
Russian Federation
39а Gorky Street, Chita, 672000
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Review
For citations:
Pashkevich А.V., Serebryakova О.V. NOS3 GENE POLYMORPHISM (G894T) IN PATIENTS WITH A COMBINATION OF BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS. Transbaikalian Medical Bulletin. 2024;(1):75-80. (In Russ.) https://doi.org/10.52485/19986173_2024_1_75
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