Ischemic stroke as a genetical disease
https://doi.org/10.52485/19986173_2022_4_107
Abstract
Ischemic stroke is a multifactorial disease, the pathogenesis of which is closely related to genetic predisposition. The results of the conducted studies indicate an increased risk of ischemic stroke in the presence of an aggravated family history. It has been established that the development of acute cerebral ischemia under the age of 65 increases the risk of acute cerebrovascular accident in the next of kin by 4 times. It is also known that stroke occurring at a young age is more associated with the carriage of various genetic polymorphisms than with the presence of cardiovascular risk factors.
The literature review presents current data on acute cerebrovascular pathology and its relationship with the carriage of various polymorphic variants of genes: the renin-angiotensin-aldosterone system (RAAS), genes that regulate endothelial function, folate metabolism, and ion channels.
About the Authors
A. Yu. Ma-Van-de
Chita State Medical Academy
Russian Federation
Russian Federation
39 A Gorkogo str., Chita, 672000
Yu. A. Vitkovsky
Chita State Medical Academy
Russian Federation
Russian Federation
39 A Gorkogo str., Chita, 672000
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Review
For citations:
Ma-Van-de A., Vitkovsky Yu.A. Ischemic stroke as a genetical disease. Transbaikalian Medical Bulletin. 2022;(4):107-113. (In Russ.) https://doi.org/10.52485/19986173_2022_4_107
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