Predictors for the development of frequent episodes of bronchial obstruction in children with acute bronchitis
https://doi.org/10.52485/19986173_2022_4_27
Abstract
Abstract. Acute respiratory infections remain an urgent problem in the practice of a pediatrician. Relationships between recurrent respiratory infections and allergic diseases have been identified. An example of such a connection is the obstructive syndrome in acute bronchitis. The article discusses the predictors of the development of acute bronchitis with episodes of obstruction in children.
The aim of the research. Identification of predictors of the development of episodes of obstruction in children with acute bronchitis.
Materials and methods. The study involved 148 pediatric patients. The children were divided into three groups: the first - children with acute bronchitis, accompanied by rare episodes of obstruction. The second group included children with acute bronchitis who had three or more episodes of obstruction per year. The control group included relatively healthy children. Statistical analysis was carried out using the Statistica software package using the criteria: Mann - Whitney, Spearman's correlation coefficient. Regression analysis was used to obtain a mathematical forecasting model.
Results and сonclusion. Predictors of the development of frequent episodes of obstruction in children with acute bronchitis were identified: a high level of IgE, low concentrations of α-defensins 1-3, a high rate of lymphocytic-platelet adhesion in blood serum, a low content of SP-D surfactant protein and a high level of Ca ++ in the condensate exhaled air. Based on the results obtained, a model for predicting the number of episodes of obstruction in children with acute bronchitis was proposed.
About the Authors
A. N. Vlasova
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky’s street, Chita, 672000
Yu. A. Vitkovsky
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky’s street, Chita, 672000
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Review
For citations:
Vlasova A.N., Vitkovsky Yu.A. Predictors for the development of frequent episodes of bronchial obstruction in children with acute bronchitis. Transbaikalian Medical Bulletin. 2022;(4):27-33. (In Russ.) https://doi.org/10.52485/19986173_2022_4_27
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