Disruption of the biological clock in adolescents with type i diabetes mellitus in remission
https://doi.org/10.52485/19986173_2022_4_19
Abstract
The aim of the research. To analyze the operation of the biological clock (perceived passage of time) in adolescents with type 1 diabetes mellitus (DM) in remission.
Materials and methods. The study involved 50 adolescents aged 13 to 18 years. The investigational group consisted of 25 adolescents with a diagnosis of type 1 DM (with a total duration of disease in these adolescents ranging from 2 to 10 years). Adolescents from the investigational group were receiving their prescribed insulin therapy and underwent hospitalization while in remission (scheduled hospitalization). The comparison group consisted of 25 patients without concomitant pathology (conditionally healthy children). Biological clock disruption was assessed using Ritm, a purpose-designed software (relying on a reference sequence of sound signals and inter-signal pauses) that was used to detect mistakes in time perception. The critical significance level for statistical hypothesis testing was specified as p≤0.05.
Results. Adolescents from the comparison group (conditionally healthy children) were overall successful in completing the task. Adolescents with DM tended to greatly decrease the total duration of the time cycle, furthermore, these patients significantly more often underestimated the mean duration of a signal and the sequence of signals produced under schemes No. 1 and 2. Moreover, the pauses held between produced signals in this group deviated to the highest extent from the “specified standard”. Therefore, patients with type 1 DM fared much worse at the task than conditionally healthy children (p≤0.01).
Conclusion. The study has revealed the presence of biological clock disruption in patients with type 1 DM in remission. Biological clock disruption may represent an underlying cause of disruptions in the activity of the central nervous system (CNS), which comprise one of the key complications in DM. A fault in the operation of the internal biological clock may serve as one of the triggers that lead to the development of type 1 DM. Timely diagnosis of biological clock disruption may provide a signal for timely initiation of treatment of CNS dysfunction in pediatric and adolescent patients with type 1 DM.
About the Authors
Yu. V. Bykov
Stavropol State Medical University
Russian Federation
Russian Federation
355017, Stavropol, Mira str., 310
V. A. Baturin
Stavropol State Medical University
Russian Federation
Russian Federation
355017, Stavropol, Mira str., 310
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Review
For citations:
Bykov Yu.V., Baturin V.A. Disruption of the biological clock in adolescents with type i diabetes mellitus in remission. Transbaikalian Medical Bulletin. 2022;(4):19-26. (In Russ.) https://doi.org/10.52485/19986173_2022_4_19
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