The relationship of oxytocin levels in blood plasma with cognitive status, anxiety and depression in patients with coronary heart disease hospitalized for coronary artery bypass grafting: preliminary data
https://doi.org/10.52485/19986173_2022_4_12
Abstract
The aim of the research. To assess the relationship between the level of oxytocin in the blood and the level of cognitive impairment, anxiety and depression in patients with coronary artery disease hospitalized for coronary artery bypass grafting.
Materials and methods. The "pilot" study included 15 men with coronary artery disease who were hospitalized for coronary artery bypass grafting. The patients' cognitive status, anxiety and depression levels were assessed, and the level of oxytocin in blood plasma was assessed using the method of enzyme immunoassay.
Results. As a result of the study, we revealed a statistically significant relationship between the level of oxytocin in blood plasma and the age of the subjects, as well as a statistically significant relationship between the level of oxytocin in blood plasma and the level of anxiety and depression in patients with coronary heart disease hospitalized for coronary artery bypass grafting. At this stage of the study, there was no statistically significant relationship between the level of oxytocin in blood plasma and cognitive deficits.
Conclusion. Oxytocin can be used as a biomarker to assess levels of anxiety and depression. In the future, with an increase in the sample size, we expect to obtain a relationship between the content of oxytocin in blood plasma and the cognitive status of patients.
About the Authors
O. V. Borovleva
Krasnoyarsk State Medical University named after Professor VF Voino-Yasenetsky
Russian Federation
Russian Federation
1 Partizan Zheleznyak Str., Krasnoyarsk, 660022
D. S. Kaskaeva
Krasnoyarsk State Medical University named after Professor VF Voino-Yasenetsky
Russian Federation
Russian Federation
1 Partizan Zheleznyak Str., Krasnoyarsk, 660022
M. M. Petrova
Krasnoyarsk State Medical University named after Professor VF Voino-Yasenetsky
Russian Federation
Russian Federation
1 Partizan Zheleznyak Str., Krasnoyarsk, 660022
O. L. Lopatina
Krasnoyarsk State Medical University named after Professor VF Voino-Yasenetsky
Russian Federation
Russian Federation
1 Partizan Zheleznyak Str., Krasnoyarsk, 660022
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Review
For citations:
Borovleva O.V., Kaskaeva D.S., Petrova M.M., Lopatina O.L. The relationship of oxytocin levels in blood plasma with cognitive status, anxiety and depression in patients with coronary heart disease hospitalized for coronary artery bypass grafting: preliminary data. Transbaikalian Medical Bulletin. 2022;(4):12-18. (In Russ.) https://doi.org/10.52485/19986173_2022_4_12
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