MULTIPLE ORGAN DYSFUNCTION IN SEVERE ACUTE ISCHEMIC STROKE OUTCOME PROGNOSIS
https://doi.org/10.52485/19986173_2021_3_33
Abstract
The aim of the research is evaluation of multiple organic dysfunction (MOD) prognostic value in outcome of patients with severe acute ischemic stroke (IS).
Materials and methods. 110 patients (49 men, 61 women) with severe acute IS (admission NIHSS ≥14) were included, onset to admission time was before 24 h. We evaluated MOD dynamic features and relation on probable mortality. We used monovariant logistic regression analysis, comparative nonlinear regression analysis for prognostic value evaluation (statistical significance level p <0,05).
Results. With insufficient outcome were associated cardioembolic subtype (p=0,023), lower GCS (p <0,001 on 3rd and 5th days), respiration dysfunction and mechanical ventilation (p<0,001 on 3rd and 5th days), vasopressors support (p=0,007 on 5th day), higher SOFA (p <0,001 on 3rd and 5th days) and SAPS-II (OR 1,15, CI 95% 1,07; 1,24; p<0,001). It revealed, that significantly higher mortality of cardioembolic subtype is seen in 30 – 45 SAPS-II (p<0,05) compare with atherotrombotic subtype.
Conclusion. MOD is one of the most important factors of severe IS outcome prognosis. Therefore, cardioembolic IS associated with worse outcome prognosis compare with atherotrombotic IS.
About the Authors
V. V. Silkin
Orenburg State Medical University; University Scientific and Clinical Center of Neurology and Neurosurgery
Russian Federation
Russian Federation
6 Sovetskaya str., Orenburg, 460000; 140V Prospect Pobedy, Orenburg, 460048
V. I. Ershov
Orenburg State Medical University; University Scientific and Clinical Center of Neurology and Neurosurgery
Russian Federation
Russian Federation
6 Sovetskaya str., Orenburg, 460000; 140V Prospect Pobedy, Orenburg, 460048
V. A. Chalyy
Orenburg State Medical University
Russian Federation
Russian Federation
6 Sovetskaya str., Orenburg, 460000
A. Yu. Bredikhin
Orenburg State Medical University
Russian Federation
Russian Federation
6 Sovetskaya str., Orenburg, 460000
T. Yu. Lozinskaya
Orenburg State Medical University
Russian Federation
Russian Federation
6 Sovetskaya str., Orenburg, 460000
E. Yu. Safronov
Orenburg State Medical University
Russian Federation
Russian Federation
6 Sovetskaya str., Orenburg, 460000
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Review
For citations:
Silkin V.V., Ershov V.I., Chalyy V.A., Bredikhin A.Yu., Lozinskaya T.Yu., Safronov E.Yu. MULTIPLE ORGAN DYSFUNCTION IN SEVERE ACUTE ISCHEMIC STROKE OUTCOME PROGNOSIS. Transbaikalian Medical Bulletin. 2021;(3):33-42. (In Russ.) https://doi.org/10.52485/19986173_2021_3_33
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