INFORMATIVE VALUE OF ROC ANALYSIS IN DETERMINING PREDICTORS OF SEVERE BRONCHIAL ASTHMA IN CHILDREN
https://doi.org/10.52485/19986173_2021_3_13
Abstract
The purpose of the study. The article considers an analytical approach to determining the diagnostic value and diagnostically significant threshold levels of growth factors in severe bronchial asthma in children.
Materials and methods. Concentrations of transforming growth factor B1 and endothelial vascular growth factor were determined in 95 patients with bronchial asthma of varying severity and 24 children of the control group. The diagnostic values of the studied factors were analyzed in the course of the ROC analysis and presented in the form of an ROC-curve.
Results and discussion. The highest concentration of growth factors was recorded in severe bronchial asthma (p). During the ROC analysis, the threshold values for TGFβ1 - 106.2 pg/ml and VEGF-A – 59.2 pg/ml were established, and the information content of each indicator was clarified. The endothelial vascular growth factor has the greatest diagnostic significance.
Conclusion. ROC analysis helps to assess the importance of diagnostic medical technologies, which allows you to improve the algorithm for diagnosing diseases.
About the Authors
N. L. Potapova
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky’s street, Chita, 672000
Yu. V. Smolyakov
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky’s street, Chita, 672000
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Review
For citations:
Potapova N.L., Smolyakov Yu.V. INFORMATIVE VALUE OF ROC ANALYSIS IN DETERMINING PREDICTORS OF SEVERE BRONCHIAL ASTHMA IN CHILDREN. Transbaikalian Medical Bulletin. 2021;(3):13-18. (In Russ.) https://doi.org/10.52485/19986173_2021_3_13
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