GENETIC PREDICTORS OF DIABETIC FOOT SYNDROME DEVELOPMENT IN MEN AND WOMEN
https://doi.org/10.52485/19986173_2021_3_1
Abstract
Purpose of the study. Analysis of the frequency of occurrence of polymorphisms C786T of the eNOS gene, Lys198Asn of the END1 gene, T1565C (Leu33Pro) of the ITGB3 gene, G1691A of the F5 gene, G20210A of the F2 gene, A8202G of the MMP9 gene, A1298C of the MTHFR gene, C634G of the VEGFA gene in women with diabetes.
Materials and methods. The polymerase chain reaction method was used to study gene polymorphisms in 72 men and 127 women with diabetic feet and 73 men and 125 women with uncomplicated diabetes mellitus. Analysis of the results included Hardy-Weinberg law compliance, Pearson's chi-square, odds ratio, and its confidence interval.
Results: In men with diabetes mellitus and diabetic foot, differences were found between the frequency of occurrence of variants of the A8202G polymorphism of the MMP9 gene. The A/G genotype was found 1.8 times more often in diabetes mellitus. The frequency of the G/G genotype in diabetic foot is 1.6 times higher. With this genotype, the risk of developing a diabetic foot doubles. In women with diabetic feet, the A/A genotype of the A1298C polymorphism of the MTHFR gene was 1.2 times more frequent. The A/C genotype in women with diabetes was found 1.5 times more often. The C/C genotype in diabetic feet was 1.4 times more common.In the presence of the A/C genotype in women, the risk of developing diabetic foot syndrome is reduced by 50%.
Conclusion. The G/G genotype of the A8202G polymorphism of the MMP9 gene in men predisposes to the development of diabetic foot. The C/C genotype of the A1298C polymorphism of the MTHFR gene in women is associated with a protective effect on the development of diabetic foot.
About the Authors
N. I. Troitskaya
Chita State Medical Academy
Russian Federation
Russian Federation
39a Gorky str., Chita,672000
K. G. Shapovalov
Chita State Medical Academy
Russian Federation
Russian Federation
39a Gorky str., Chita,672000
V. A. Mudrov
Chita State Medical Academy
Russian Federation
Russian Federation
39a Gorky str., Chita,672000
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Review
For citations:
Troitskaya N.I., Shapovalov K.G., Mudrov V.A. GENETIC PREDICTORS OF DIABETIC FOOT SYNDROME DEVELOPMENT IN MEN AND WOMEN. Transbaikalian Medical Bulletin. 2021;(3):1-7. (In Russ.) https://doi.org/10.52485/19986173_2021_3_1
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