Reverse transport of cholesterol and its regulation through molecular mechanisms (message 2)
https://doi.org/10.52485/19986173_2021_1_95
Abstract
The multistage process of reverse cholesterol transport is under the control of microRNAs, which have been widely studied in recent decades. MicroRNAs control intracellular lipid synthesis, transport of lipids, including cholesterol, from the cell and the entry of LP into the cell, LP formation, β-oxidation of fatty acids. Thus, microRNAs take part in lipid metabolism at different stages. Some of microRNAs control the reverse flow of cholesterol. At the stage of cholesterol outflow from foam cells and the formation of mature HDL particles, an important role is played by microRNAs that regulate the expression of ATP-binding cassette transporters A1(ABCА1) and G1 (ABСG1); these are miR-33 a / b, miR-758, miR-144, miR-26, miR-27a / b, miR-148a, miR-128-1, miR-302a. It has also been shown that microRNAs are involved in the selective uptake of cholesterol through class B, type I scavenger receptors for HDL in the liver: miR-185, miR-96, miR-223, miR-125, miR-145. Due to the extensive participation of miRNAs in the reverse flow of cholesterol, they are of interest as therapeutic targets for the correction of atherosclerosis. There is evidence of an increase in plasma HDL when miR-33is inhibited. Another microRNA (miR-223) may be a predictor of myocardial infarction.
About the Authors
L. O. Gutsol
Irkutsk state medical University
Russian Federation
Russian Federation
1 Krasnogo Vosstaniya str., Irkutsk, 664003
L. N. Minakina
Irkutsk state medical University
Russian Federation
Russian Federation
1 Krasnogo Vosstaniya str., Irkutsk, 664003
I. E. Egorova
Irkutsk state medical University
Russian Federation
Russian Federation
1 Krasnogo Vosstaniya str., Irkutsk, 664003
I. Z. Seminskiy
Irkutsk state medical University
Russian Federation
Russian Federation
1 Krasnogo Vosstaniya str., Irkutsk, 664003
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Review
For citations:
Gutsol L.O., Minakina L.N., Egorova I.E., Seminskiy I.Z. Reverse transport of cholesterol and its regulation through molecular mechanisms (message 2). Transbaikalian Medical Bulletin. 2021;(1):95-102. (In Russ.) https://doi.org/10.52485/19986173_2021_1_95
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