THE INFLUENCE OF THE ADAPTATION STATUS OF HEMODYNAMIC REGULATION ON THE MATRIX OF HEMODYNAMIC INDICES

The aim of the research. To study the effect of adaptation status on microcirculation parameters measured by dynamic light scattering (mDLS) in healthy volunteers, patients with confirmed chronic pathologies and athletes.

Materials and methods. The experimental study involved 149 individuals of both sexes, aged 21 ± 4 years. The subjects were divided into three groups based on their fitness level: 96 somatically healthy subjects, 25 subjects with chronic somatic pathology, and 28 subjects who regularly exercised. The mDLS study included four stages: rest, recording of parameters, physical activity (10 squats), and recording of parameters. Each recording consisted of five phases with alternating blood flow occlusion.

Results. Under control conditions, baseline microcirculation parameters were comparable between groups. Under stress, pronounced microcirculation activation was observed in all groups, with the most noticeable changes in healthy and sick subjects. Athletes demonstrate increased stability. Post-occlusive hyperemia enhances the effects of stress, especially in healthy individuals. Group differences are confirmed by parameter correlations and visualized in graphs.

Conclusion. The hemodynamic index matrix is an effective tool for noninvasively assessing the functional state of the microcirculatory bed and the degree of cardiovascular adaptation under the influence of stress and adaptation. The identified hyperreactivity of the endothelial component can serve as a prognostic marker for depletion of adaptive reserves in pathology. The microcirculation pattern characteristic of athletes can be considered a target for rehabilitation measures.

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