TOLL-like receptor-3 genetic polymorphism in patients with influenza A(H3N2) and influenza B
https://doi.org/10.52485/19986173_2021_1_17
Abstract
Aim was to study the genetic TLR3 (Leu412Phe) polymorphism in patients with influenza A(H3N2) and influenza B.
Methods. The study was performed in 89 patients with influenza A(H3N2) and 80 patients with influenza Baged 15 to 82 years (the average age was 49.0±14.0 years) and 96 healthy residents. The TLR3 gene polymorphism was detected by PCR method.
Results. It was shown that the frequency of the allele -412Leu of the TLR3 gene was significantly higher than among healthy respondents (frequency in patients with influenza A(H3N2) - 0.433, influenza B - 0.325, among healthy people - 0.249; p˂0.05) an increase in the relative risk of the development of this pathology equal to: in patient with influenza A(H3N2) in carriers of the Leu412Leu gene TLR3 – OR=2,39 [СI95%: 1,04-3,61], in patient with influenza B in carriers of the Leu412Phegene TLR3 – OR=2,41 [CI95%: 1,29-4,43].
Conclusion. The -412Leu allele of the Toll-like receptor-3 gene predisposes to the development of influenza A (H3N2) and B.
About the Authors
A. S. Emelyanov
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky’s street, Chita, 672000
G. A. Chuprova
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky’s street, Chita, 672000
A. N. Emelyanova
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky’s street, Chita, 672000
Yu. A. Vitkovsky
Chita State Medical Academy
Russian Federation
Russian Federation
39a, Gorky’s street, Chita, 672000
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Review
For citations:
Emelyanov A.S., Chuprova G.A., Emelyanova A.N., Vitkovsky Yu.A. TOLL-like receptor-3 genetic polymorphism in patients with influenza A(H3N2) and influenza B. Transbaikalian Medical Bulletin. 2021;(1):17-21. (In Russ.) https://doi.org/10.52485/19986173_2021_1_17
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