The pattern of circulating micrornas in acute myocardial infarction
https://doi.org/10.52485/19986173_2025_2_140
Abstract
Acute myocardial infarction (AMI) is a potential life-threatening complication of coronary heart disease and occupies a leading place in the mortality structure of the population. In recent years, methods of early diagnosis of AMI and comorbid conditions have been improved, which can play an important role in a personalized approach to therapy and prediction of outcomes and complications. The problem of developing and introducing new sensitive and specific biochemical and molecular biomarkers of AMI into real clinical practice is of great interest to Russian and foreign researchers.
The purpose of this thematic review is to search, summarize and systematize the results of fundamental and clinical studies of the role of microRNAs as sensitive and specific molecular biomarkers of AMI.
The authors conducted a search for publications in the databases PubMed, Web of Science, Scopus, Cochrane Library, Springer, ClinicalKey, Oxford Press, e-Library using keywords and their combinations. Publications from 2009–2024, including original clinical studies of AMI, were analyzed. As a result of this review, it was shown that circulating miR-1, miR-133a, and miR-208a can be considered promising molecular biomarkers of AMI. The presented brief review indicates that the early diagnosis of AMI has prospects for development due to the development and introduction into real clinical practice of new laboratory tests, including the study of the level of circulating microRNAs in the blood from the first hours of the development of acute coronary syndrome.
Keywords
myocardial infarction,
acute coronary syndrome,
diagnosis,
biomarker,
blood,
microRNA,
personalized medicine
Supporting agencies: The work was carried out as part of the state assignment of the Krasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky of the Ministry of Health of the Russian Federation (2023–2025). "Development of a personalized algorithm for diagnosing vascular moderate cognitive dysfunction in patients with acute myocardial infarction based on new genetic and biochemical biomarkers", No. 123022800057-6
About the Authors
М. М. Petrova
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Head of the Department
Department Polyclinic Therapy with Course of Postgraduate Education
660022; 1 Partizan Zheleznyak St.; Krasnoyarsk
Researcher ID: L-5623-2014; Elibrary (Author ID): 613080; Author ID (Scopus): 23987271200
N. A. Shnayder
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; V.M. Bekhterev National Research Medical Center for Psychiatry and Neurology
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, General Researcher, Leading Researcher
Institute of Personalized Psychiatry and Neurology; Center of Collective Usage
«Molecular and Cell Technologies»
660022; 1 Partizan Zheleznyak St.; Krasnoyarsk; 192019; 3 Bekhterev St.; St. Petersburg
Researcher ID: M-7084-2014; Elibrary (Author ID): 185359; Author ID (Scopus): 24503222300
D. V. Dmitrenko
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Associate Professor, Head of the Department, Head of the Center, Head of the Laboratory
IPE; Department of Medical Genetics and Clinical Neurophysiology; Neurological Center for Epileptology, Neurogenetics and Brain Research; Laboratory of Medical Genetics
660022; 1 Partizan Zheleznyak St.; Krasnoyarsk
Researcher ID: H-7787-2016; Elibrary (Author ID): 614958; Author ID (Scopus): 55413907300
A. V. Petrov
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Student
660022; 1 Partizan Zheleznyak St.; Krasnoyarsk
Researcher ID: AGZ-3730-2022; Elibrary (Author ID): 1154385; Author ID (Scopus): 5737505540
D. S. Kaskaevа
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Candidate of Medical Science, Associate Professor, Head of the Department
Department Polyclinic Therapy with Course of Postgraduate Education; Department of General Medical Practice
660022; 1 Partizan Zheleznyak St.; Krasnoyarsk
Researcher ID: S-8106-2016; Elibrary (Author ID): 543648; Author ID (Scopus):
48662493200
A. A. Evsyukov
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation
Russian Federation
Candidate of Medical Science, Associate Professor
Department Polyclinic Therapy with Course of Postgraduate Education
660022; 1 Partizan Zheleznyak St.; Krasnoyarsk
Elibrary (Author ID): 543649; Author ID (Scopus): 6602687133
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Review
For citations:
Petrova М.М., Shnayder N.A., Dmitrenko D.V., Petrov A.V., Kaskaevа D.S., Evsyukov A.A. The pattern of circulating micrornas in acute myocardial infarction. Transbaikalian Medical Bulletin. 2025;(2):140-151. (In Russ.) https://doi.org/10.52485/19986173_2025_2_140
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