Effectiveness of correction of zinc and macronutrient deficiency in new coronavirus infection

   The aim study to the effectiveness of zinc and macronutrient deficiency correction in patients with new coronavirus infection.

   Materials and Methods. In 2021–2023, a comprehensive clinical and laboratory examination of 641 patients with a new coronavirus infection was carried out at the Perm Regional Clinical Infectious Diseases Hospital. Using the envelope method, 2 groups of 43 people with protein and zinc deficiency were formed. In group the first, the nutritional status was corrected with the sipping mixture "Supportan" 100,0 x 3 times a day per os, for a course of 14–21 days, as well as a zinc preparation of 25,0 mg per os for a course of 10–14 days. In the second group additional correction with micro- and macroelements was not carried out, the therapy was carried out in accordance with current clinical guidelines. The observation time for patients corresponded to their stay in the hospital, as well as in the period of early convalescence. The course of the disease, duration of intoxication syndrome, complications that arose during the disease, fatal outcomes in both groups, and the presence of asthenia during convalescence were assessed. The results of the study were processed using the statistical software package Statistica 10.0.

   Results. In group the first, by day 4 (3; 5) of therapy, 90,6 ± 4,5 % showed a decrease in intoxication symptoms, in group the second, by day 5 (4; 6), in 74,4 ± 6,7 % (p = 0,012) and p = 0,046, respectively. A decrease in the volume of previously visible consolidation zones in the lungs and "ground glass" zones on days 10–14 of therapy in group 1 was recorded in 40 people (93,0 ± 3,9 %), in group 2 – in 33 people (76,7 ± 6,4 %), p = 0,033. On the background of correction with a sipping mixture and a zinc preparation, the nutritional status deficiency was stopped in group 1 by days 14–21, and CRP, IL-6, and procalcitonin levels quickly regressed. During the early recovery period in group 1, asthenia was detected in 32,5 ± 7,1 % of patients, in group 2 – in 60,4 ± 7,5 % (p = 0,008).

   Conclusion. Correction of deficiency of the main representatives of the protein pool and zinc during therapy of patients with COVID-19 reduces the duration of intoxication syndrome, accelerates the process of tissue restoration after an infectious disease, and also improves the physical condition of the patient during the period of early convalescence.

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