THE ROLE OF MYOKINES IN IMPROVING COGNITIVE FUNCTION
https://doi.org/10.52485/19986173_2024_4_126
Abstract
Over the past couple of decades, it has become apparent that skeletal muscles work as an endocrine organ that can produce and secrete myokines that exert their effects in an endocrine, paracrine, or autocrine manner. Modern research shows that physical exertion induces the synthesis of molecules involved in the transmission of signals between skeletal muscle cells and other organs, in particular the brain, adipose tissue, organs of the gastrointestinal tract, as well as skin and vascular cells. This review examines the myokines that cause communication with the brain, neuroprotection in response to physical activity and related processes. Unlike exercise-induced protective myokines and related signaling pathways, physical inactivity and muscle wasting can disrupt the expression and secretion of myokines and, in turn, disrupt the function of the central nervous system. It is assumed that adapting the transmission of signals from muscles to the brain by modulating myokines will help combat age-related neurodegeneration and brain diseases affected by systemic signals.
About the Authors
A. I. Petrova
Chita state medical academy
Russian Federation
Russian Federation
Petrova A.I., Candidate of Medical Sciences, assistant of the Department of Pediatrics
AuthorID: 963027,
Scopus AuthorID: 57201847102
39а Gorky St., Chita, Russia, 672000
A. V. Markovskiy
Chita state medical academy
Russian Federation
Russian Federation
Markovskiy A.V., Candidate of Medical Sciences, assistant of the Department of Pathological Physiology
AuthorID: 824262,
Scopus AuthorID: 57454161000
39а Gorky St., Chita, Russia, 672000
N. I. Potapova
Chita state medical academy
Russian Federation
Russian Federation
Potapova N.L., Doctor of Medical Sciences, docent, Head of the Department of Polyclinic Pediatrics with a course of medical rehabilitation
AuthorID: 639640,
Scopus AuthorID: 57216661611
39а Gorky St., Chita, Russia, 672000
Yu I. Mizernitskiy
Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Mizernitskiy Yu.L., Doctor of Medical Sciences, Professor, Head of the Department of Chronic, Inflammatory and Allergic Diseases lung diseases of Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery and Professor of the Department of Innovative Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University
AuthorID: 963027,
Scopus AuthorID: 57201847102
2, Taldomskaya St., Moscow, Russia, 125412
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For citations:
Petrova A.I., Markovskiy A.V., Potapova N.I., Mizernitskiy Yu.I. THE ROLE OF MYOKINES IN IMPROVING COGNITIVE FUNCTION. Transbaikalian Medical Bulletin. 2024;(4):126-132. (In Russ.) https://doi.org/10.52485/19986173_2024_4_126
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