The parameters of daily pH-impedancemetry in patients with comorbidity of gastroesophageal reflux disease and obstructive sleep apnea syndrome

Objective. To evaluate the parameters of daily pH-impedancemetry of the esophagus monitoring in case of comorbidity of gastroesophageal reflux disease (GERD) and obstructive sleep apnea syndrome (OSAS) in comparison with monopathology of GERD.

Materials and methods. A cross-sectional study was conducted at the therapeutic department of the private healthcare institution Hospital “RZD medicine” in Irkutsk of two groups of patients: with GERD and GERD in combination with OSAS. GERD was verified in accordance with the clinical recommendations of the Russian Gastroenterological Association (2020), Lyon Consensus 2.0 (2024). The diagnosis of OSAS was established in accordance with the criteria of the Eurasian Association of Cardiologists and the Russian Society of Sleep Medicine (2024). Statistical processing of the obtained data was performed using Statistica 10.0 (StatSoft, USA).

Results. The GERD group included 14 patients (46,7%), the GERD and OSAS group included 16 patients, the groups were comparable by age and gender. In the GERD and OSAS group, compared with the GERD group, the following were higher: total AET (p = 0,04), in the supine position during sleep (p = 0,002); Demeester index (p = 0,013); duration of refluxes (p = 0,007); total number of refluxes (p = 0,06); in the supine position during sleep, the total number of refluxes (p = 0,002) and the number of refluxes reaching 19 cm above the LES (p = 0,051). In the GERD and OSAS group, compared with the GERD group, MNBI at the Z1 level (p = 0,003) and the PSPW index (p = 0,05) were lower.

Conclusion. In case of comorbidity of GERD and OSAS, in comparison with GERD, more pronounced low and high acid reflux, especially in the supine position, impaired esophageal clearance with a decrease in the MNBI and PSPW index were found.

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