Гормональная регуляция нейрогенеза

Ключевым процессом для изучения нейропластичности выступает нейрогенез и участие в нём гормонов. Цель настоящего обзора состоит в анализе новейших данных, полученных исследователями в этой области, и формировании общего представления о молекулярных механизмах действия гормонов на этапы нейрогенеза. Изучена литература, включающая научные отечественные и зарубежные публикации, которые были подготовлены преимущественно за последние пять лет.

Методами исследования выступали анализ первоисточников и научных результатов, полученных другими авторами. Использование сравнительного анализа позволило исследовать и сопоставить виды действия гормонов в зависимости от места их синтеза. Применение системно-структурного метода позволило сформировать авторскую схему, отображающую влияние гормонов на нейрогенез.

В обзоре рассматривается влияние гормонов на нейрогенез. Установлено, что снижение концентрации гормонов или нарушение их метаболизма может выступать причиной развития патологических состояний. Выявлено сходство нейронных и сосудистых сетей в механизмах их роста и развития.

Сформулирован вывод о необходимости изучения механизмов взаимосвязи нейрогенеза и ангиогенеза с целью выявления новых молекул, регулирующих активность пронейрогенных или проангиогенных клеток.

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