Post-stroke depressive disorders: a contemporary perspective on etiology, genetics and pathogenesis
https://doi.org/10.52485/19986173_2025_2_130
Abstract
Disability after store is caused not only by motor, speech, and other focal neurological symptoms but also by neuropsychiatric disorders. Post-stroke depression (PSD) complicates the effectiveness of rehabilitation measures, reduces the efficacy of treatment for concomitant diseases, exacerbates and increases mortality. This article reviews contemporary perspectives on the prevalence, etiology, pathogenesis, and genetics of post-stroke depression based on scientific literature. The pathogenesis of depression is significantly influenced by the metabolism of biogenic amines, thus particular attention is paid to genetic factors of serotonin metabolism disorders and its role in the development of ADD. Pro-inflammatory cytokines are considered as potential markers of high risk for depression development. Literature on post-stroke anxiety (PSA) is scarce, especially regarding the combination of PSA and PSD. However, the presence of anxiety in patients with PSD prolongs its duration, increases its severity, and significantly reduces the effectiveness of rehabilitation measures.
Keywords
stroke,,
depression,
anxiety-depressive disorders,
serotonin,
SLC6A4 gene polymorphism,
Val66Met polymorphism of the BDNF gene
Supporting agencies: No funding was provided for this work
About the Authors
D. V. Shishigin
North-Eastern Federal University named ofter M.K. Ammosov
Russian Federation
Russian Federation
Postgraduate student, Neurologist
Neurology Department for Patients with Acute Cerebrovascular Disorders
677000; 58 Belinskogo st.; Yakutsk
T. Ya. Nikolaeva
North-Eastern Federal University named ofter M.K. Ammosov
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Head of the Department
Department of «Neurology and Psychiatry»
677000; 58 Belinskogo st.; Yakutsk
A. A. Tappakhov
North-Eastern Federal University named ofter M.K. Ammosov
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor
Department of «Neurology and Psychiatry»
677000; 58 Belinskogo st.; Yakutsk
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Shishigin D.V., Nikolaeva T.Ya., Tappakhov A.A. Post-stroke depressive disorders: a contemporary perspective on etiology, genetics and pathogenesis. Transbaikalian Medical Bulletin. 2025;(2):130-139. (In Russ.) https://doi.org/10.52485/19986173_2025_2_130
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