The role of thrombin in the development of inflammation
https://doi.org/10.52485/19986173_2025_1_107
Abstract
Thrombin is the main driver of the linker mechanism for immune response and hemostasis. Due to its specific structure, which determines the selectivity of functional activity against cells of the inflammatory microenvironment, this serine proteinase is actively involved in the processes of inflammation and healing, carcinogenesis and pathological processes of immunity. The uniqueness of its action is revealed due to the presence of special receptors activated by proteinases (PARs). Such factors as their expression on different cell types, the spatiotemporal amount of thrombin, the localization of the pathological process in the body, pathology in the hemostasis and immunity system will determine the variants of events mediated by the presented serine proteinase.
The review presents current information on some mechanisms of interaction between the main effector cells of inflammation and thrombin with the participation of PARs. The molecular structure of the latter and the dependence of their functional activity on conformational states are considered. The role of thrombin as one of the main regulators of the immunoinflammation process is highlighted.
About the Authors
D. S. Belousov
Chita State Medical Academy
Russian Federation
Russian Federation
Daniil S. Belousov - postgraduate student of the Department of Normal Physiology named after Professor B.I. Kuznik.
39a Gorky st., Chita, 672000
Author ID РИНЦ 1261731
A. V. Solpov
Chita State Medical Academy
Russian Federation
Russian Federation
Alexey V. Solpov - Doctor of Medical Sciences, Associate Professor, Professor of the Department of Normal Physiology named after Professor B.I. Kuznik, Leading Researcher at the Laboratory of Physiology and Pathology of Hemostasis at the Research Institute of Molecular Medicine.
39a Gorky st., Chita, 672000
Researcher ID JVZ-8040-2024, Author ID РИНЦ 440891, Author ID Scopus 13406034300
Yu. A. Vitkovsky
MEDLUX multidisciplinary medical center
Russian Federation
Russian Federation
Yuri A. Vitkovsky - Doctor of Medical Sciences, Professor, allergologist-immunologist.
97/1 Babushkina St., Chita, 672039
Researcher ID AAH-4250-2019, Author ID РИНЦ 288798, Author ID Scopus 6603125558
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For citations:
Belousov D.S., Solpov A.V., Vitkovsky Yu.A. The role of thrombin in the development of inflammation. Transbaikalian Medical Bulletin. 2025;(1):107-120. (In Russ.) https://doi.org/10.52485/19986173_2025_1_107
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