Antioxidants in the prevention of nervous system disorders in diabetes mellitus
https://doi.org/10.52485/19986173_2023_4_56
Abstract
Diabetes mellitus (DM) is one of the most common metabolic diseases with a large number of complications. Disorders of the nervous system (NS) are the main complication of DM, the pathophysiology of which is not fully understood. The dysfunction of the central nervous system against the background of DM primarily includes diabetic encephalopathy (DE) and peripheral polyneuropathy (PP). Oxidative stress (OS) is considered one of the leading hypotheses leading to NS disorders in DM. In addition, OS is discussed as one of the pathophysiological links in the development of type 1 and type 2 DM. OS causes mitochondrial dysfunction, neuroinflammation, with a parallel decrease of the antioxidant system, having a negative effect on the brain. The important role of the OS in the occurrence of PP is discussed. Antioxidants (AO) have direct indications for the correction of central nervous system disorders in DM. Preclinical studies have shown the preventive role of various AO in DE and PP. Further clinical studies are needed to substantiate the appointment of AO in the prevention of NS disorders in DM.
About the Author
Yu. V. Bykov Yu.V.
Stavropol State Medical University; City Children's Clinical Hospital named after G.K. Filippsky
Russian Federation
Russian Federation
310 Mira str., Stavropol, 355017
5 Ponomareva str., Stavropol, 355002
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For citations:
Bykov Yu.V. Yu.V. Antioxidants in the prevention of nervous system disorders in diabetes mellitus. Transbaikalian Medical Bulletin. 2023;(4):56-66. (In Russ.) https://doi.org/10.52485/19986173_2023_4_56
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