CLINICAL AND LABORATORY ASPECTS OF DIFFERENTIAL DIAGNOSTICS OF ALIMENTARY-TOXIC PAROXYSMAL MYOGLOBINURIA WITH SOME INFECTIOUS DISEASES
https://doi.org/10.52485/19986173_2023_2_159
Abstract
The geographical distribution, pathogenesis and clinical picture of alimentary-toxic paroxysmal myoglobinuria (ATPM) are considered. Data are presented for the differential diagnosis of ATPM with hemorrhagic fever with renal syndrome, leptospirosis, trichinosis and enterovirus infection, including anamnestic data, pathogenesis, pathomorphology, clinical manifestations, complications and laboratory data. Difficulties in the differential diagnosis of ATPM with these diseases may arise due to the presence of similar symptoms and the coincidence of the localization of natural foci of diseases.
Hemorrhagic fever with renal syndrome is distinguished from ATPM by the presence of high fever, hemorrhagic syndrome, visual impairment, thrombocytopenia, the absence of significant myolysis and myoglobinuria. In contrast to ATPM, jaundice, meningeal and hemorrhagic syndromes, exanthema, lymphadenopathy, hyperbilirubinemia and thrombocytopenia are observed in leptospirosis. The main differences of trichinosis with ATPM are edematous syndrome, severe blood eosinophilia and possible eosinophilic infiltration of lung tissue. With enterovirus infection, in contrast to alimentary-toxic myoglobinuria, serous meningitis, enanthema and exanthema can be observed.
About the Authors
V. I. Starostina
Bashkir State Medical University
Russian Federation
Russian Federation
3 Lenina str., Ufa, 450008
A. Zh. Gilmanov
Bashkir State Medical University
Russian Federation
Russian Federation
3 Lenina str., Ufa, 450008
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For citations:
Starostina V.I., Gilmanov A.Zh. CLINICAL AND LABORATORY ASPECTS OF DIFFERENTIAL DIAGNOSTICS OF ALIMENTARY-TOXIC PAROXYSMAL MYOGLOBINURIA WITH SOME INFECTIOUS DISEASES. Transbaikalian Medical Bulletin. 2023;(2):159-172. (In Russ.) https://doi.org/10.52485/19986173_2023_2_159
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