THE EFFECT OF CYTOFLAVIN ON THE ETIOLOGICAL STRUCTURE AND FREQUENCY OF BACTEREMIA IN PATIENTS WITH SEVERE COMBINED TRAUMA

Military Medical Academy named after S.M. Kirov, 6 Academician Lebedev str, St. Petersburg, 194014 The aim of the research. To assess the effect of the substrate antihypoxant Cytoflavin on the frequency of bacteremia and the type of microorganisms sown in severe combined trauma.

Materials and methods. The results of bacterial cultures and PCR-analysis of venous blood of 2 groups of victims who received severe concomitant injuries accompanied by shock of the 2nd and 3rd degree are presented. The main group - 39 patients treated with Cytoflavin, and the control group - 41 patients in whose treatment Cytoflavin was not used. To assess bacteremia, bacterial cultures and PCR-analysis of venous blood of the victims were used. For statistical processing, we used the assessment of the reliability of differences in the means of disconnected (independent) samples according to the t-test (Student) and the assessment of the normality of the distribution using the Kolmogorov-Smirnov test.

Results. Fungi of the genus Candida, St. haemolyticus, Corynebacterium spp., Klebsiella pneumoniae, Toxoplasma gondii, E. coli, Ps. aeruginosa, Acinetobacter baumannii, Enterobacter spp., St. pneumoniae, Enterobacter cloacae, Ps. alcaligenes, gr. + cocci, Pseudomonas spp. In the main group, 76,9 % of negative cultures were obtained, in the control group, only 24 %. The maximum number of positive blood cultures was observed on the 3rd and 5th days in the control group. Most often, 2 microorganisms were sown in the 1st sample, no stable combinations were obtained. 

Conclusion. The revealed signs of an almost 3-fold decrease (from 76.9 % in the control group to 24 % in the main group) in the frequency of blood cultures suggest a positive effect of the use of the cytoflavin substrate antihypoxant in the treatment of patients with severe concomitant trauma.

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